|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Diabetes disease stage was marginally significantly associated with the frequency of the T variant at rs12255372 (p=0.057; adjusted p=0.017) but not at rs7903146 (p=0.5; adjusted p=0.2).
|
18282631 |
2008 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Diabetes-associated variation (T allele at rs7903146) in TCF7L2 may impair the ability of hyperglycemia to suppress glucagon (45 ± 2 vs. 47 ± 2 vs. 60 ± 5 ng/L for CC, CT, and TT, respectively, P = 0.02).
|
22461567 |
2012 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
rs7903146 T allele is associated with diabetes and, in non-diabetic individuals, with a higher prevalence and severity of coronary artery disease and cardiovascular events. name of registry site (see list below), registration number, trial registration URL in brackets.
|
19924244 |
2009 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
A variant in TCF7L2 associated with type 2 diabetes (the T allele at rs7903146) was associated with diabetes in CF in the family study (p = 0.004) and in the case-control study (p = 0.02; combined p = 0.0002).
|
19585101 |
2009 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Allele-specific PCR assay to genotype SNP rs7903146 in TCF7L2 gene for rapid screening of diabetes susceptibility.
|
19169495 |
2008 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Analysis of TCF7L2 rs7903146 in normal controls and diabetics with or without nephropathy demonstrated that the 'T' allele is associated with both diabetes (p = 0.049) and DN (p = 0.024), but this association is not independent of T2DM.
|
25185853 |
2014 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes.
|
26914832 |
2016 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Concerned with predisposition for diabetes mellitus in obese children, we tested if risk genotypes TC and TT of rs7903146 are more common in obese children with increased homeostasis model assessment insulin resistance index (HOMA-IR) compared to obese controls with normal HOMA-IR.
|
18546086 |
2008 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
For four candidate SNPs (rs780094, rs10830963, rs7903146, and rs4607517), the strength of association between genotype and glucose was significantly (P-interaction<0.05) different in those with and without prevalent diabetes, and for all five fasting glucose candidate SNPs (rs780094, rs10830963, rs560887, rs4607517, and rs13266634) the association with measured fasting glucose was more significant in the smaller sample without prevalent diabetes than in the larger combined sample of those with and without diabetes.
|
20839289 |
2010 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genetic variation in TCF7L2 rs7903146 and history of GDM negatively and independently impact on diabetes-associated metabolic traits.
|
30419301 |
2018 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, the T allele (conferring higher risk of diabetes) at rs7903146 was associated with higher fasting proinsulin at baseline (P<0.001), higher baseline proinsulin:insulin ratio (p<0.0001) and increased proinsulin:insulin ratio over a median of 2.5 years of follow-up (P = 0.003).
|
21814547 |
2011 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Human genetic studies have revealed that the T minor allele of single nucleotide polymorphism rs7903146 in the transcription factor 7-like 2 (TCF7L2) gene is strongly associated with an increased risk of diabetes by 30%-40%.
|
25058603 |
2014 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
In subjects without known diabetes (n=961) recruited from the Chennai Urban Rural Epidemiology Study (CURES), OGTT, IDRS, and genotyping of rs12255372 (G/T) and rs7903146(C/T) of TCF7L2 polymorphisms were done.
|
21441683 |
2011 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, we aimed to confirm the effect of the TCF7L2 polymorphism rs7903146 on diabetes risk in a Brazilian population and to assess the use of this genetic marker in improving diabetes risk prediction in the general population.
|
19055834 |
2008 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Of 100K SNPs, one (rs7100927) was in moderate LD (r2 = 0.50) with TCF7L2 (rs7903146), and was associated with risk of diabetes (Cox p-value 0.007, additive hazard ratio for diabetes = 1.56) and with tFPG (GEE p-value 0.03).
|
17903298 |
2007 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study provides the first significant evidence of association between the TCF7L2 rs7903146 polymorphism and type 2 diabetes risk in a large African American population and also demonstrates that the diabetes risk conveyed by the rs7903146 risk allele is substantially increased in the context of some metabolic risk factors for type 2 diabetes.
|
18931037 |
2009 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study revealed no differences in the kinetics of glucose, insulin, C-peptide and non-esterified fatty acids during an OGTT in homozygous participants from a German diabetes risk cohort (n = 1832) carrying either the rs7903146 CC (n = 15) or the TT (n = 15) genotype.
|
24925104 |
2014 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Over an average follow-up period of 5.43 years, participants with the rs7903146 T allele or variants in the same LD block, but not those with the rs290481 G allele, were more likely to progress to diabetes (hazard ratio = 2.61, 95% confidence interval, 1.27-5.39, P = 0.009) than were non-carriers.
|
19806338 |
2010 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Over an average period of three years, participants with the risk-conferring TT genotype at rs7903146 were more likely to have progression from impaired glucose tolerance to diabetes than were CC homozygotes (hazard ratio, 1.55; 95 percent confidence interval, 1.20 to 2.01; P<0.001).
|
16855264 |
2006 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant.
|
20980453 |
2011 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Risk alleles of the TCF7L2 gene showed increased risk of diabetes even when controlled for traditional diabetes risk factors (diabetes in family, waist circumference, physical activity, BMI, SBP and total and HDL-cholesterol) in both a cross-sectional and prospective setting (cross-sectional: rs12255372 OR 1.61 (1.31-1.99), rs7903146 OR 1.48 (1.20-1.83) and prospective: rs12255372 OR 1.59 (1.22-2.07), rs7903146 OR 1.47 (1.11-1.93)).
|
18972257 |
2009 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Role of rs7903146 polymorphism and adropin serum level in patients with diabetes mellitus; a case-control study from Isfahan, Iran.
|
31818149 |
2019 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
TCF7L2 rs7903146 C>T polymorphism is associated with diabetes in the general population but its independent impact on cardiovascular disease is debated.
|
28299838 |
2017 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
The FHS cohort supported these results: The rs7903146 T allele was significantly associated with lower estimated GFR (P = 0.01) and higher cystatin C (P = 0.004) in adjusted analyses overall and among those without diabetes.
|
18650481 |
2008 |
|
rs7903146
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
The minor allele frequency for rs7903146 was different between TCP and FCPD patients carrying the N34S SPINK1 variant but did not reach statistical significance (OR = 1.59, 95% CI = 0.93-2.70, P = 0.09), while, TCF7L2variant showed a statistically significant association between TCP and FCPD patients carrying the 26V allele (OR = 1.69, 95% CI = 1.11-2.56, P = 0.013).
|
18706099 |
2008 |