|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene (NOS3) has been characterized as a risk factor of hypertension and coronary artery disease.
|
21816783 |
2011 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A meta-analysis of 35 genetic association studies that examined the relation between hypertension and the G894T, 4a/b, T786C, and G23T polymorphisms of the endothelial nitric oxide synthase gene was carried out.
|
16940230 |
2006 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of endothelial nitric oxide synthase (eNOS) gene G894T polymorphism with hypertension risk and complications.
|
27557897 |
2016 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further studies are needed to reveal the usefulness of G894T polymorphism in hyper</span>tension risk assessment in obese.
|
26579574 |
2015 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Furthermore, meta-regression analysis indicated that the effect of the Glu298Asp genotype on the risk of hypertension might be dependent on total cholesterol status.
|
17762636 |
2007 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genotype frequencies for the -786T/C, 4b/4a, and 894G/T polymorphisms differed significantly (P<0.001) between patients and controls and were associated with an increased risk of hypertension (OR=2.0, OR=3.8, OR=1.6, respectively).
|
18325347 |
2008 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, a subgroup analysis adjusted with various cardiovascular risk factors confirmed positive association of the -786T>C polymorphism in CAD patients with hypertension and a smoking history and also a significant association of the intron 4 genotypes with a smoking history, but no significance has been found in the eNOS polymorphisms of 894G>T upon any risk adjustment.
|
16842840 |
2007 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, GG phenotype of Glu298Asp polymorphism neither decreased the ESRD risk (OR = 0.77, 95% CI 0.55-1.08, P = 0.13) nor affected the hypertension risk (OR = 1.04, 95% CI 0.66-1.66, P = 0.86).
|
24995932 |
2014 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, a missense Glu298Asp mutation in exon 7 of the eNOS gene is reported to be a risk factor for hypertension or myocardial infarction.
|
12701818 |
2003 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Intron 4 B/B genotype was significantly associated with the hypertension group (P = 0.035), but disequilibrium of G894T and T-786C was absent between the two groups (P = 0.419 and P = 0.227), respectively.
|
17024134 |
2006 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Multiple logistic regression revealed that the most predictive independent risk factor for coronary spasm was the T-786-->C mutation (P < 0.001), followed by cigarette smoking (P < 0.001), hypertension (P = 0.004), and the Glu298Asp variant (P = 0.028).
|
10979242 |
2000 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
No differences were observed in the distribution of G894T (Glu298Asp) NOS3 genotypes between the resistant hypertension group and the controlled hypertension patients.
|
19650939 |
2009 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data suggests that 894G>T plays a significant role in the mechanistic interaction between metabolic risk such as hypertension and MS, although sex-related differences may exist.
|
19169496 |
2008 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall, our findings suggest that eNOS G894T and T-786C SNPs were both significantly correlated with hypertension</span>.
|
28287883 |
2017 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Previous studies regarding endothelial nitric oxide synthase (eNOS) Glu298Asp polymorphism focused upon its relation to hypertension.
|
17594145 |
2007 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, a G894T polymorphism in exon 7 of the eNOS gene has been reported to be associated with high blood pressure.
|
18164968 |
2008 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Regarding the eNOS E298D polymorphism, the frequency of the mutant D allele carriage was only observed to be higher among cases with hypertension associated with diabetes and obesity, in comparison with controls, yet not reaching statistical significance (41.2% vs. 34%, p > 0.05).
|
23042814 |
2013 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Relation of the Glu298Asp polymorphism of the nitric oxide synthase gene to hypertension and serum cholesterol in Japanese workers.
|
18550157 |
2008 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Studies on the associations between the nitric oxide synthase gene (NOS3) Glu298Asp polymorphism and hypertension status or blood pressure (BP) levels have had inconsistent results.
|
15505116 |
2004 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Glu298Asp, T786C and 4a/4b genetic polymorphisms within the endothelial nitric oxide synthase (e-NOS) gene may predispose to hypertension, ischaemic heart disease and renal damage, possibly by reducing the generation of nitric oxide (NO), a fundamental substance in renal and cardiovascular biology.
|
17563560 |
2007 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The AGT M235T and eNOS G894T polymorphisms are unlikely to play an important role in the pathogenesis of hypertension in Malays.
|
17977523 |
2008 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of our study is to investigate whether genetic polymorphisms in the endothelial nitric oxide synthase (eNOS) gene (in the promoter region T(-786)C, in exon 7 (Glu298Asp) and in intron 4 (4b/4a)) or eNOS haplotypes are associated with hypertension in obese children and adolescents.
|
20661250 |
2011 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The genotypic distribution of the Met235Thr (AGT) and Glu298Asp (NOS3) polymorphisms demonstrated that both are independent risk factors of hypertension (p=0.02 and p=0.008, respectively).
|
22791701 |
2013 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The NOS3 -786 T/C (SNP id rs2070744; http://www.ensembl.org ), intron 4 variable number tandem repeat (VNTR), and Glu298Asp (SNP id rs1799983) polymorphisms, have been associated with differences in NO plasma concentrations and with the risk of hypertension (HT) and ischemic cardiac disease.
|
21293869 |
2011 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The polymorphism Glu298Asp of endothelial nitric oxide (eNOS) gene has been associated with hypertension and coronary artery disease in several populations worldwide, but results are still controversial.
|
20083095 |
2010 |