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rs1042309696
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Pharmacogenetic association of the NPPA T2238C genetic variant with cardiovascular disease outcomes in patients with hypertension.
|
18212314 |
2008 |
|
rs1042309696
|
|
Cardiovascular Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
The NPPA T2238C variant was associated with modification of antihypertensive medication effects on cardiovascular disease and BP.
|
18212314 |
2008 |
|
rs1156835126
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated a possible association between hypertension and haptoglobin, angiotensin I-converting enzyme (ACE), glutathione S-transferases GSTM1 and GSTT1, MnSOD (Val9Ala), CAT (-21A/T), and GPX1 (Pro198Leu) gene polymorphisms in an urban Brazilian population group from Brasília.
|
21053180 |
2010 |
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rs1157043147
|
|
Diabetic Nephropathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggest that TGF-beta T869C (Leu 10Pro) gene polymorphism is associated with DMN in Chinese.
|
12675860 |
2003 |
|
rs1181835738
|
|
Venous Thromboembolism
|
|
0.010 |
GeneticVariation
|
BEFREE |
Statistically significant associations with VTE were identified for factor V G1691A (OR 9.45; 95% CI 6.72-13.30, p < 0.0001), factor V A4070G (OR 1.24; 95% CI 1.02-1.52, p = 0.03), prothrombin G20210A, (OR 3.17; 95% CI 2.19-3.46, p < 0.00001), prothrombin G11991A, (OR 1.17; 95% CI 1.07-1.27, p = 0.0007), PAI-1 4G/5G, (OR 1.62; 95% CI 1.22-2.16, p = 0.0008), alpha-fibrinogen Thr312Ala (OR 1.37; 95% CI 1.14-1.64, p = 0.0008), all in Caucasian populations.
|
19652888 |
2009 |
|
rs1205538057
|
|
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation
|
BEFREE |
G-containing genotypes (AG + GG) and G allele of AT2R in intron 1 (A1675G) were more frequent in SLE patients compared to controls ( p = 0.01, OR = 2.3, 95% CI = 1.2-4.5; p = 0.02, OR = 2.1, 95% CI = 1.2-3.7, respectively).
|
30621494 |
2019 |
|
rs1205538057
|
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
A slight impact of AT2R 1675G/A polymorphism on CAD was found only in female diabetic patients.
|
22345093 |
2012 |
|
rs1205538057
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
1675G/A variant in the AT2R gene was found to be associated with CAD in female subjects with type 2 diabetes (p = 0.025).
|
22345093 |
2012 |
|
rs1205538057
|
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
High renin-angiotensin system activity and the A-allele of the AT2R 1675G/A polymorphism associate with high risk of severe hypoglycemia in type 1 diabetes.
|
18328310 |
2008 |
|
rs121912703
|
|
Hyperactive behavior
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we describe a first family outside Europe with asymptomatic autosomal-dominant hyper-ACE-emia due to the ACE Pro1199Leu mutation.
|
16958600 |
2006 |
|
rs1221928144
|
|
Essential Hypertension
|
|
0.010 |
GeneticVariation
|
BEFREE |
This is the first report showing that the S89N single-nucleotide polymorphism of the UTS2 gene is associated with essential hypertension.
|
16866021 |
2007 |
|
rs1241356540
|
|
Diabetic Retinopathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, our results suggest that V16A polymorphism of the Mn-SOD gene is not related to the development of diabetes and progression of DR, but is associated with DME in Korean type 2 diabetic patients.
|
17142144 |
2006 |
|
rs1241356540
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study was designed to investigate whether V16A polymorphism of the manganese superoxide dismutase (Mn-SOD) gene is associated with the development of type 2 diabetes mellitus and with progression of diabetic retinopathy (DR) and diabetic macular edema (DME).
|
17142144 |
2006 |
|
rs1241356540
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, our results suggest that V16A polymorphism of the Mn-SOD gene is not related to the development of diabetes and progression of DR, but is associated with DME in Korean type 2 diabetic patients.
|
17142144 |
2006 |
|
rs1241356540
|
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, our results suggest that V16A polymorphism of the Mn-SOD gene is not related to the development of diabetes and progression of DR, but is associated with DME in Korean type 2 diabetic patients.
|
17142144 |
2006 |
|
rs1241356540
|
|
Diabetic macular edema
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, our results suggest that V16A polymorphism of the Mn-SOD gene is not related to the development of diabetes and progression of DR, but is associated with DME in Korean type 2 diabetic patients.
|
17142144 |
2006 |
|
rs1267969615
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings suggest that the angiotensin-converting enzyme I/D and angiotensinogen M235T polymorphisms are unlikely to correlate with colorectal cancer.
|
31642377 |
2020 |
|
rs1267969615
|
|
Malignant neoplasm of colon and/or rectum
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings suggest that the angiotensin-converting enzyme I/D and angiotensinogen M235T polymorphisms are unlikely to correlate with colorectal cancer.
|
31642377 |
2020 |
|
rs1267969615
|
|
Muscle damage
|
|
0.010 |
GeneticVariation
|
BEFREE |
Muscle damage was also determined fifteen days after race and angiotensinogen (<i>AGT</i>) Met235Thr, angiotensin-converting enzyme (<i>ACE</i>) I/D, and Bradykinin B2 receptor (<i>BDKRB2</i>) -9/+9 polymorphisms were determined.
|
31708962 |
2019 |
|
rs1267969615
|
|
Acute myocardial infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
There was a significant difference in the insertion deletion genotype distribution between two groups (P = 0.03) and a higher percentage of the T allele M235T polymorphism in the group of STEAMI patients (P = 0.02).
|
29474203 |
2018 |
|
rs1267969615
|
|
Metabolic Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of the study was to investigate the association between ACE (I/D) and AGT (M235T) gene polymorphisms and cardiovascular and metabolic disorders in the acromegaly.
|
28712073 |
2017 |
|
rs1267969615
|
|
CARDIOMYOPATHY, FAMILIAL RESTRICTIVE, 1 (disorder)
|
|
0.010 |
GeneticVariation
|
BEFREE |
Also, 235TT genotype of AGT (M235T) was significantly associated with enhanced risk of the disease phenotype in HCM, DCM, and RCM.
|
28120210 |
2017 |
|
rs1267969615
|
|
Hyperaldosteronism
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among polymorphisms, only AGT M235T (P = 0.038) was associated with refractory hyperaldosteronism, after adjustment for nongenetic variables.
|
25036270 |
2015 |
|
rs1267969615
|
|
Left ventricular systolic dysfunction
|
|
0.010 |
GeneticVariation
|
BEFREE |
We enrolled 109 consecutive patients with left ventricular systolic dysfunction [left ventricular ejection fraction (LVEF) 32 ± 10%; 86% males; age 65 ± 13 years (mean ± standard deviation)] on optimized adrenergic and renin-angiotensin-aldosterone system (RAAS) antagonism, undergoing clinical and neuroendocrine characterization, and genotyping for six polymorphisms in key RAAS-regulating genes [angiotensinogen (AGT M235T), angiotensin-converting enzyme (ACE-240A>T and I/D), angiotensin II type I receptor (AGTR1 1166A>C), aldosterone synthase (CYP11B2-344C>T) and renin (REN rs7539596)].
|
25036270 |
2015 |
|
rs1267969615
|
|
Renal cyst
|
|
0.010 |
GeneticVariation
|
BEFREE |
The allele frequency of AGT M235T differed significantly between group 1 (patients with simple renal cysts and hypertension) and normal individuals (p < 0.05).
|
23907112 |
2015 |