|
rs12922061
|
|
Breast Carcinoma
|
|
0.720 |
GeneticVariation
|
BEFREE |
Our study found that rs12922061 of LOC643714 was related to breast cancer risk.
|
29683073 |
2018 |
|
rs12922061
|
|
Breast Carcinoma
|
|
0.720 |
GeneticVariation
|
BEFREE |
Our findings suggested that LOC643714 rs3803662, rs8051542, rs12443621, and rs12922061 polymorphisms were all significantly associated with BC in certain populations.
|
31324582 |
2019 |
|
rs12922061
|
|
Breast Carcinoma
|
T |
0.720 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of breast cancer in the Japanese population.
|
24143190 |
2013 |
|
rs3104746
|
|
Breast Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The study discovered for the first time that three SNPs (rs9933638, rs12443621, and rs3104746) at the TOX3/LOC643714 locus contributed to lung cancer risk, providing new evidences that lung cancer and breast cancer are linked at the molecular and genetic level to a certain extent.
|
27486757 |
2016 |
|
rs3104746
|
|
Breast Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The strongest association was observed for rs3104746: each copy of the A-rs3104746 allele was associated with a 23% higher risk of breast cancer (odds ratios, 1.23; 95% confidence intervals, 1.05-1.44; P=0.009).
|
20406955 |
2010 |
|
rs3104793
|
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, four other SNPs (rs3104746, rs3112562, rs3104793, and rs8046994), all of them located in the LOC643714 gene, were associated with risk of breast cancer.
|
20406955 |
2010 |
|
rs3112612
|
|
Breast Carcinoma
|
T |
0.710 |
GeneticVariation
|
GWASCAT |
Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.
|
21263130 |
2011 |
|
rs3112612
|
|
Breast Carcinoma
|
|
0.710 |
GeneticVariation
|
BEFREE |
No significant association existed between rs12443621, rs3803662, and rs3112612 polymorphisms and risk of breast cancer.
|
24481062 |
2014 |
|
rs3803662
|
|
Breast Carcinoma
|
A |
0.900 |
GeneticVariation
|
GWASCAT |
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
|
23535729 |
2013 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Given that <i>TOX3</i> mRNA is a target of miR-182, and that both the <i>TOX3</i> rs3803662-T and pri-miR-182 rs4541843-T alleles are associated with increased BC risk, we evaluated their combined effect.
|
30135399 |
2018 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently, genetic polymorphism (rs3803662C>T) in TOX3 was reported to induce the risk of breast cancer.
|
24069142 |
2013 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
No statistically significant association was found between the rs3803662 polymorphism and breast cancer in patients or healthy controls.
|
29683073 |
2018 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Conclusively, this meta-analysis suggests that TNRC9 rs3803662 polymorphism was significantly correlated with breast cancer risk and the variant T allele of TNRC9 rs3803662 polymorphism is a low-penetrant risk factor for developing breast cancer.
|
20703937 |
2011 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The present meta-analysis suggests that rs3803662 polymorphism is significantly associated with breast cancer risk in Caucasian women, and we did not find the association in Asian women.
|
27350156 |
2016 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
A dose-dependent association was observed between the risk of breast cancer and the genetic risk score, which was an aggregate measure of alleles in seven selected variants, namely FGFR2-rs2981579, TOX3/TNRC9-rs3803662, C6orf97-rs2046210, 8q24-rs13281615, SLC4A7-rs4973768, LSP1-rs38137198, and CASP8-rs10931936.
|
22160591 |
2012 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Significant associations with BC were observed for rs3803662 (dominant comparison: OR, 0.89; 95% CI, 0.84-0.95; P = .0008; recessive comparison: OR, 1.17; 95% CI, 1.07-1.28; P = .0004; over-dominant comparison: OR, 1.07; 95% CI, 1.02-1.11; P = .002; allele comparison: OR, 0.90; 95% CI, 0.86-0.95; P = .0002), rs8051542 (dominant comparison: OR, 0.87; 95% CI, 0.83-0.91; P < .0001; recessive comparison: OR, 1.19; 95% CI, 1.11-1.28; P < .0001; over-dominant comparison: OR, 1.07; 95% CI, 1.02-1.11; P = .004; allele comparison: OR, 0.89; 95% CI, 0.86-0.91; P < .0001), and rs12922061 (dominant comparison: OR, 0.83; 95% CI, 0.73-0.93; P = .002; over-dominant comparison: OR, 1.43; 95% CI, 1.27-1.61; P < .0001) polymorphisms in the overall population.
|
31324582 |
2019 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Two index SNPs were associated with breast cancer: rs3803662 at 16q12.2/TOX3 (Hazard ratio [HR] for the T allele = 0.79, 95% CI: 0.67-0.92, P = 0.003) and rs10941679 at 5p12 (HR for the G allele = 1.31, 95% CI: 1.06-1.63, P = 0.014).
|
21795501 |
2011 |
|
rs3803662
|
|
Breast Carcinoma
|
T |
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
|
23535733 |
2013 |
|
rs3803662
|
|
Breast Carcinoma
|
A |
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies five new breast cancer susceptibility loci.
|
20453838 |
2010 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
With the exception of rs3803662 (TOX3), there was no evidence that any of the SNPs associated with BC susceptibility were associated with the BC survival.
|
22532573 |
2012 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The known breast cancer SNPs rs13281615, rs2981582 and rs3803662 were confirmed as associated with breast cancer risk (P (allelic test) = 1.8 x 10(-2), OR = 1.17; P (allelic test) = 2.2 x 10(-3), OR = 1.22; P (allelic test) = 5.1 x 10(-2), OR = 1.15, respectively) in the West of Ireland cohort.
|
19005751 |
2009 |
|
rs3803662
|
|
Breast Carcinoma
|
A |
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
|
25751625 |
2015 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
BC patients (n = 1687) randomly sampled in an adjuvant, randomized phase III trial (SUCCESS A study) were genotyped for nine BC risk SNPs: rs17468277 <i>(CASP8)</i> , rs2981582 <i>(FGFR2)</i> , rs13281615(8q24), rs3817198 <i>(LSP1)</i> , rs889312 <i>(MAP3K1)</i> , rs3803662 <i>(TOX3)</i> , rs13387042(2q35), rs4973768 <i>(SLC4A7)</i> , rs6504950 <i>(COX11)</i> .
|
28757652 |
2017 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The results suggest that the effect of the risk allele of rs3803662 is strongest in luminal A tumours and that the expression levels of TOX3 and/or LOC643714 affect the progression of breast cancer.
|
23270421 |
2012 |
|
rs3803662
|
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In the validation study using Stage I of the 2,273 cases and 2,052 controls, seven GWAS-identified loci [5q11.2/MAP3K1 (rs889312 and rs16886165), 5p15.2/ROPN1L (rs1092913), 5q12/MRPS30 (rs7716600), 6q25.1/ESR1 (rs2046210 and rs3734802), 8q24.21 (rs1562430), 10q26.13/FGFR2 (rs10736303), and 16q12.1/TOX3 (rs4784227 and rs3803662)] were significantly associated with breast cancer risk in Korean women (Ptrend < 0.05).
|
22452962 |
2012 |