|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
We investigated whether polymorphism 1858C>T in PTPN22 gene is associated with susceptibility to allergic asthma and RA in a Polish population.
|
17579671 |
2007 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis confirms that the PTPN22 C1858T polymorphism is associated with RA susceptibility in different ethnic groups, especially in Europeans, and the PTPN22 C1858T polymorphism T allele is significantly more prevalent in RF-positive patents than in RF-negative patients.
|
21706348 |
2012 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
Results showed that 1858 C/T PTPN22 SNP significantly (P = 0.007, OR = 2.321, 95% CI = 1.063-5.067) associated with RA.
|
31669381 |
2019 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
This association is independent of the well-established association between PTPN22 R620W and RA.
|
21279993 |
2011 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
The PTPN22 1858C/T polymorphism has been associated with several autoimmune diseases including rheumatoid arthritis (RA).
|
17553139 |
2007 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
Our data not only establish a molecular link between PTPN22 and PAD-4, but also suggest that the C1858T SNP increases the risk of RA by enhancing protein citrullination and spontaneous formation of NETs.
|
26019128 |
2015 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
This meta-analysis confirms that the PTPN22 C1858T polymorphism is associated with RA susceptibility in different ethnic groups, especially in Europeans, and the PTPN22 C1858T polymorphism T allele is significantly more prevalent in RF-positive patents than in RF-negative patients.
|
23370857 |
2013 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
Our meta-analysis demonstrated that PTPN22 rs2476601 and STAT4 rs7574865 polymorphisms confers susceptibility to RA in total subjects and in major ethnic groups.
|
25963842 |
2015 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
Childhood-onset RA was associated with TNFAIP3 rs10499194 (OR 0.60 [95% confidence interval 0.44-0.83]), PTPN22 rs2476601 (OR 1.61 [95% confidence interval 1.11-2.31]), and STAT4 rs7574865 (OR 1.41 [95% confidence interval 1.06-1.87]) variants.
|
23450725 |
2013 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
Consistent interaction, defined as departure from additivity, between HLA-DRB1 SE alleles and the A allele of PTPN22 R620W was seen in all three studies regarding anti-CCP-positive RA.
|
17436241 |
2007 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
The disease association of the common 1858C>T Arg620Trp (rs2476601) nonsynonymous single nucleotide polymorphism (SNP) of protein tyrosine phosphatase; nonreceptor type 22 (PTPN22) on chromosome 1p13 has been confirmed in type 1 diabetes and also in other autoimmune diseases, including rheumatoid arthritis and Graves' disease.
|
18305142 |
2008 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
Our study shows for the first time a marked down-regulation of PTPN22 expression in RA patients carrying the risk alleles of PTPN22 rs2488457 and rs2476601 compared to controls (p = 0.004 and p = 0.007, respectively).
|
28874816 |
2017 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
Here we aimed to examine the associations of the PTPN22 R620W and R263Q polymorphisms with susceptibility to or protection against rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and Graves' disease (GD) among Mexican patients.
|
28500376 |
2017 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
To investigate genotype-phenotype correlation and gene-environment interaction between PTPN22 R620W environmental factors such as tobacco/hormonal treatments in an inception cohort of RA patients.
|
21752868 |
2011 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
Having previously reported significant association of the T allele of rs2476601 in a Graves' disease (GD) cohort, we sought to determine whether novel rheumatoid arthritis-associated SNPs were also contributing to susceptibility to GD.
|
17148556 |
2007 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism of PTPN22, 1858C>T (rs2476601), disrupts an interaction motif in the protein, and is the most important non-HLA genetic risk factor for rheumatoid arthritis and the second most important for juvenile idiopathic arthritis.
|
25003765 |
2014 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
Protein tyrosine phosphatase gene C1858T allele confers risk for rheumatoid arthritis in Hungarian subjects.
|
19034456 |
2009 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
A missense single-nucleotide polymorphism (SNP) within this gene (rs2476601) has recently been associated with 4 autoimmune diseases: rheumatoid arthritis (RA), systemic lupus erythematosus, autoimmune thyroid disease, and type 1 diabetes mellitus, all of which are T cell-mediated and associated with the elaboration of autoantibody.
|
15934099 |
2005 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
However, we were able to replicate the association signals between RA and HLA-DRB1 alleles, STAT4 (rs7574865), PTPN22 (rs2476601) and OLIG3/TNFAIP3 (rs10499194 and rs6920220).
|
19445664 |
2009 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
We studied RA risk associated with PTPN22 (rs2476601), PADI-4 (rs2240340), and CTLA-4 (rs3087243) in the Nurses' Health Study (NHS) and NHSII.
|
18462498 |
2008 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
The SNP rs2476601 located in the PTPN22 gene is the sole common genetic variant associated with RA in the 1p13.2 region, suggesting that neighbor genes of PTPN22 do not have a major influence in RA.
|
21965649 |
2011 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
The functional PTPN22 C1858T polymorphism was associated with an increased risk for RA in our study population.
|
26951256 |
2016 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
PTPN22 has emerged strongly as a genuine rheumatoid arthritis susceptibility gene with replications of the association to the R620W single nucleotide polymorphism.
|
16462519 |
2006 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn's disease, in Canadian populations.
|
15986374 |
2005 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
PTPN22 1858C>T polymorphism distribution in Europe and association with rheumatoid arthritis: case-control study and meta-analysis.
|
21949702 |
2011 |