|
rs2294008
|
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our study suggested rs2294008 in the PSCA gene to be associated with increased risk of gastric cancer and rs2070803 in MUC1 to play a protective role in a Chinese population.
|
22938426 |
2012 |
|
rs2294008
|
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Although modest limitations and potential bias cannot be eliminated, this meta-analysis suggests that PSCA -rs2294008C>T and -rs2976392G>A are potential factors of GC development for Eastern Asians, and future work may incorporate these findings and evaluate these variants as potential markers for screening and early diagnosis of GC.
|
22155405 |
2012 |
|
rs2294008
|
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The rs2294008 polymorphism in PSCA increases the risk of noncardia gastric cancer and its precursors in white individuals but protects against proximal cancers.
|
21070776 |
2011 |
|
rs2294008
|
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our study showed that rs2294008 in the PSCA gene was associated with increased risks of gastric cancer in a Korean population, suggests that rs2294008 might play an important role in gastric carcinogenesis.
|
21538581 |
2011 |
|
rs2294008
|
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
If validated in further studies, PSCA rs2294008</span> could be useful marker of sur</span>vival assessment and individualized clinical therapy for gastric cancer, particularly among the diffuse-type gastric cancer.
|
21064099 |
2011 |
|
rs2294008
|
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
In conclusion, The T allele of PSCA rs2294008 is associated with increased risk of gastric cancer, especially intestinal type, poorly differentiated, early onset, and noncardia gastric cancer in Chinese population.
|
21268123 |
2011 |
|
rs2294008
|
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Recently, two genome-wide association studies identified a significant association between the prostate stem cell antigen (PSCA) rs2294008 (C>T) polymorphism and risk of diffuse-type of gastric cancer in Asians and bladder cancer in Caucasians, respectively.
|
20083643 |
2010 |
|
rs2294008
|
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Two single nucleotide polymorphisms (SNPs) (rs2976392 and rs2294008) in the PSCA gene were recently identified as the susceptibility loci of gastric cancer, especially in diffuse type.
|
20131315 |
2010 |
|
rs2294008
|
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The rs2294008 C/T polymorphism of the PSCA gene was significantly associated with the susceptibility to GC.
|
20230293 |
2010 |
|
rs2294008
|
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We found that rs2294008 and rs2976392, which were strongly linked to each other (D' = 1.00), were significantly associated with stomach cancer risk.
|
19582881 |
2009 |
|
rs4072037
|
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our study confirms the protective effect of MUC1 rs40</span>72037 polymorphism on the risk of GC under the dominant model.
|
28489708 |
2018 |
|
rs4072037
|
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our data suggested that rs4072037 polymorphism was associated with a decreased risk of GC.
|
28561882 |
2017 |
|
rs4072037
|
|
Stomach Carcinoma
|
T |
0.800 |
GeneticVariation
|
GWASCAT |
Identification of new susceptibility loci for gastric non-cardia adenocarcinoma: pooled results from two Chinese genome-wide association studies.
|
26701879 |
2017 |
|
rs4072037
|
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Published data on the association between the MUC1 rs4072037A > G polymorphism and gastric cancer (GCa) risk were inconclusive.
|
26910281 |
2016 |
|
rs4072037
|
|
Stomach Carcinoma
|
A |
0.800 |
GeneticVariation
|
GWASCAT |
We also confirmed a previously reported association for rs4072037 in MUC1 with p=6.59×10(-8) for total gastric cancer and similar estimates for cardia and non-cardia cancers.
|
26129866 |
2016 |
|
rs4072037
|
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population.
|
26910281 |
2016 |
|
rs4072037
|
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Those subjects with both the risk alleles MUC1 rs9841504 and ZBTB20 rs4072037 had a greater than 3-fold increased risk of gastric cancer.
|
27127881 |
2016 |
|
rs4072037
|
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Loss-of-function variants in ATM confer risk of gastric cancer.
|
26098866 |
2015 |
|
rs4072037
|
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Several genetic variants including PSCA rs2294008 C>T and rs2976392 G>A, MUC1 rs4072037 T>C, and PLCE1 rs2274223 A>G have shown significant association with stomach cancer risk in the previous genome-wide association studies (GWASs).
|
25658482 |
2015 |
|
rs4072037
|
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Further, subgroup analysis based on ethnicity suggested MUC1 rs4072037 polymorphism had a subtly reduced cancer risk among Asian population, and stratified analysis by cancer types showed significantly decreased risk of gastric cancer in all genetic models.
|
24755768 |
2014 |
|
rs4072037
|
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We found that the rs4072037 AG genotype was significantly associated with a reduced risk of gastric cancer [odds ratios (OR) = 0.78; 95% confidence interval (CI) = 0.67-0.91 for AG vs AA].
|
24254309 |
2014 |
|
rs4072037
|
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The aim of this study was to determine whether rs4072037A > G in MUC1 at 1q22 and rs2274223A > G in PLCE1 at 10q23 are associated with a risk of gastric cancer in a Korean population.
|
24254309 |
2014 |
|
rs4072037
|
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Polymorphisms of PSCA (rs2976392, rs2294008) and MUC1 (rs4072037) genes are associated with GC and HRAG.
|
25503145 |
2014 |
|
rs4072037
|
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The G allele of MUC1 rs4072037 was significantly associated with a decreased risk of GC (OR = 0.72, 95 % CI 0.68-0.77; P = 7.82 × 10(-25)), as compared with A allele.
|
24072653 |
2013 |
|
rs4072037
|
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
These findings indicate that the three SNPs (rs4072037, rs13361707 and rs2274223) identified in the GWASs may interact with H. pylori infection to increase the risk of GC.
|
24069371 |
2013 |