|
rs2010963
|
|
Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
Genomic DNA was isolated from whole blood for the analysis of <i>VEGF-A</i> (rs2010963, 1570360, rs699947), <i>ICAM-1</i> (rs5498, rs1799969) SNPs and from tumor tissue for the detection of genomic variants in <i>KRAS</i>, <i>NRAS</i>, <i>BRAF</i> genes.
|
31752122 |
2019 |
|
rs2010963
|
|
Coronary Arteriosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Moreover, VEGF rs699947 and rs2010963 polymorphisms may serve as genetic biomarkers of poor collateral circulation after myocardial ischemia.
|
30317903 |
2018 |
|
rs2010963
|
|
Glioma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Also, the VEGF polymorphisms rs3024994, rs2010963, and particularly the homozygous carriers of rs1005230 were associated with a worse prognosis for glioma and glioblastoma.
|
29584591 |
2018 |
|
rs2010963
|
|
Coronary heart disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Besides, rs3025039 polymorphism was significantly correlated with the number of affected coronary arteries, while rs699947 and rs2010963 polymorphisms were significantly correlated with poor collateral circulation in CHD patients.
|
30317903 |
2018 |
|
rs2010963
|
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
As to rs1570360 or rs2010963, we did not observe any relationship between the two polymorphisms and RCC risk in our study.
|
28356760 |
2017 |
|
rs2010963
|
|
Coronary heart disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
In conclusion, our findings suggest that VEGFA rs699947 C>A, rs3025039 C>T and rs2010963 G>C polymorphisms are risk factors for CHD.
|
28430629 |
2017 |
|
rs2010963
|
|
Psoriasis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our results indicate that VEGF (rs2010963) polymorphism and CTC haplotype of the VEGF SNPs (rs699947, rs833061, and rs2010963) confer an increased risk of psoriasis in the South Indian Tamil population.
|
28803785 |
2017 |
|
rs2010963
|
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggested that there may be a relationship between the VEGF rs2010963, rs3025039 and rs699947 polymorphisms and RCC susceptibility.
|
28562357 |
2017 |
|
rs2010963
|
|
Glioma
|
|
0.030 |
GeneticVariation
|
BEFREE |
The haplotype analysis demonstrated that two SNPs of VEGF [rs3025039 (C>T), rs2010963 (G>C)] could elevate the susceptibility to a glioma in the homozygous model [odds ratio (OR) = 3.13 (95% confidence interval (CI) 1.30-7.49, P = 0.007) and OR = 1.58 (95% CI 1.07-2.34, P = 0.022), respectively], dominant model [OR = 1.38 (95% CI 1.04-1.84, P = 0.025) and OR = 1.32 (95% CI 1.01-1.72, P = 0.043), respectively], and allelic model [OR = 1.43 (95% CI 1.11-1.84, P = 0.005) and OR = 1.24 (95% CI 1.04-1.50, P = 0.019), respectively].
|
26093379 |
2016 |
|
rs2010963
|
|
Coronary heart disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Angiotensin converting enzyme insertion/deletion (I/D) (rs4646994) and Vegf polymorphism (+405G/C; rs2010963) in type II diabetic patients: Association with the risk of coronary artery disease.
|
24505095 |
2015 |
|
rs2010963
|
|
Coronary Arteriosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Angiotensin converting enzyme insertion/deletion (I/D) (rs4646994) and Vegf polymorphism (+405G/C; rs2010963) in type II diabetic patients: Association with the risk of coronary artery disease.
|
24505095 |
2015 |
|
rs2010963
|
|
Psoriasis
|
|
0.030 |
GeneticVariation
|
BEFREE |
The aim of this meta-analysis was to investigate large-scale evidence to determine the degree to which four common VEGF polymorphisms (+405C>G [dbSNP: rs2010963], -460T>C [dbSNP: rs833061], -2578C>A [dbSNP: rs699947], and -1154G>A [dbSNP: rs1570360]) are associated with susceptibility to psoriasis.
|
24678886 |
2014 |
|
rs2010963
|
|
Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
After stratifying by tumor molecular subtype, SNP associations observed for colon cancer were: VEGFA rs2010963 with CIMP+ colon tumors; FLT1 rs4771249 and rs7987649 with TP53; FLT1 rs3751397, rs7337610, rs7987649, and rs9513008 and KDR rs10020464, rs11941492, and rs12498529 with MSI+ and CIMP+/KRAS2-mutated tumors.
|
23794399 |
2014 |
|
rs2010963
|
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our results indicate that VEGFA rs2010963 and VEGFR3 rs448012 are associated with risk of ccRCC.
|
25239121 |
2014 |
|
rs2010963
|
|
Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
Blood and tumor tissue from 83 patients with NSCLC were examined for VEGF -460T/C (rs833061) and VEGF +405G/C (rs2010963) SNPs using the SNaPshot method.
|
23064377 |
2013 |
|
rs2010963
|
|
Glioma
|
|
0.030 |
GeneticVariation
|
BEFREE |
In the single-locus analysis, we found that rs2010963 (G+405C, G-634C) [odds ratio (OR) = 1.29; 95% confidence interval (CI) = 1.04-1.58; GC/CC vs. GG] and rs3025030 (OR = 2.21; 95% CI = 1.18-4.14; CC vs. GG/GC) were associated with increased risk for glioma, and rs3024994 (OR = 0.66; 95% CI = 0.47-0.94; CT/TT vs. CC) was associated with reduced glioma risk, albeit insignificant after Bonferroni correction for multiple comparisons.
|
20209496 |
2011 |
|
rs2010963
|
|
Coronary Arteriosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
We examined two VEGF polymorphisms, including +405 C/G (rs2010963) and -2578C/A (rs699947), to assess their relation to the extent of coronary atherosclerosis.
|
20489684 |
2010 |
|
rs2010963
|
|
Polycystic Ovary Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our study shows for the first time that the rs2010963 polymorphism may be associated with a risk of PCOS in Northern Chinese women.
|
30935253 |
2019 |
|
rs2010963
|
|
Glioblastoma Multiforme
|
|
0.020 |
GeneticVariation
|
BEFREE |
Also, the VEGF polymorphisms rs3024994, rs2010963, and particularly the homozygous carriers of rs1005230 were associated with a worse prognosis for glioma and glioblastoma.
|
29584591 |
2018 |
|
rs2010963
|
|
Glioblastoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Also, the VEGF polymorphisms rs3024994, rs2010963, and particularly the homozygous carriers of rs1005230 were associated with a worse prognosis for glioma and glioblastoma.
|
29584591 |
2018 |
|
rs2010963
|
|
Renal Cell Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
As to rs1570360 or rs2010963, we did not observe any relationship between the two polymorphisms and RCC risk in our study.
|
28356760 |
2017 |
|
rs2010963
|
|
Renal Cell Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggested that there may be a relationship between the VEGF rs2010963, rs3025039 and rs699947 polymorphisms and RCC susceptibility.
|
28562357 |
2017 |
|
rs2010963
|
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found that the VEGF rs2010963 CG + GG genotypes had a significantly increased risk of hand-foot syndrome, and the ABCB1 rs1045642 CT + TT genotypes had an increased risk of high blood pressure.
|
26830973 |
2016 |
|
rs2010963
|
|
Polycystic Ovary Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
Increased and reduced PCOS risk was seen with rs3025020 and rs2010963 genotypes, respectively.
|
27846231 |
2016 |
|
rs2010963
|
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Also, adjusted ORs in the presence of normolipidemia and the absence of history of hypertension for the risk of CAD in the either ACE(rs4646994) D allele or VGEF(rs2010963)-G alleles were 2.08 (p=0.004) and 1.75 (p=0.024), respectively.
|
24505095 |
2015 |