|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Single-nucleotide polymorphisms rs12979860 and rs8099917 within the IFNL gene locus predict hepatitis C virus (HCV) clearance, as well as inflammation and fibrosis progression in viral and non-viral liver disease.
|
28513591 |
2017 |
|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Associations between viral load and demographic, obstetrical, HCV risk factors, and interleukin-28B gene (IL28B) polymorphism (rs12979860) were assessed.
|
28903504 |
2017 |
|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
HCV genotype (P=0.007), IFNL3 rs12979860 (CC) (P=0.023), IFNL3 rs12980275 (AA) (P=1 × 10<sup>-4</sup>), EGFR rs11506105 (AA) (P=0.005), RVR (P=1 × 10<sup>-4</sup>), and cEVR (P=0.003) were significant predictors for SVR.
|
28703131 |
2017 |
|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although these 2 SNPs, rs8099917 and rs12979860, have established their significant roles in the innate immunity response to spontaneously clear HCV in patients with AHC, the detailed mechanisms of their roles remain largely unknown.
|
29040985 |
2017 |
|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Single genetic nucleotide polymorphism (rs12979860) near the gene for interleukin 28B (IL28B) is known to be of importance for frequency of spontaneous clearance and treatment outcome in interferon-based therapies in patients with hepatitis C virus (HCV) infection.
|
28820758 |
2017 |
|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
One hundred eight HCV chronically infected patients initiating treatment with pegylated IFN plus ribavirin for 48 wk were tested for baseline substitutions at codons 70 and 91 of the viral core protein (BigDye Terminator vers.3.1, Applied Biosystems,) and for genetic polymorphisms in host <i>IL28B</i> gene rs12979860 (Custom TaqMan 5' allelic discrimination assay; Applied Biosystems).
|
27729747 |
2016 |
|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
We analyzed 230 TM patients with HCV infection (mean age 36.0±6.3 years; 59.1% genotype 1; 32.2% genotype 2; 3.4% genotype 3; and 5.3% genotype 4; 28.7% carried CC allele of rs12979860 in IL28B locus; 79.6% had chronic hepatitis and 20.4% cirrhosis; 63.5% naive and 36.5% previously treated with interferon alone) treated in 14 Italian centers.
|
27012446 |
2016 |
|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
the Interferon lambda (IFNL) polymorphisms genotypes (rs8099917, rs12979860 and rs12980275) and the presence of mutations in HCV core protein were analyzed in 59 patients with HCC, and also in 50 cirrhotic patients (without HCC).
|
27035616 |
2016 |
|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of IL28B SNPs rs12979860 and rs8099917 on Hepatitis C Virus-RNA Status in Donors/Recipients of Living Donor Liver Transplantation.
|
27275739 |
2016 |
|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Favourable genotypes of IFNL3 polymorphism CC for rs12979860 and TT for rs8099917 are strongly associated with the interferon/ribavirin treatment outcome in hepatitis C virus (HCV) patients with genotypes 1 and 4.
|
27498543 |
2016 |
|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of the present study was to verify the genotype frequencies of SNPs rs8099917, rs12979860 and rs368234815 and to evaluate the association between SNPs and the outcome of HCV infection, taking into account the population ancestry.
|
26973228 |
2016 |
|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
A prospective study was conducted including 474 (250 genotype 1, 224 genotype 2) consecutive chronic hepatitis C (CHC) patients who had completed an anti-HCV therapy course and undergone pre-therapy and 24-week post-therapy assessments of interferon λ3-rs12979860 and HCV RNA/genotypes, anthropometric measurements, metabolic and liver profiles, and complement component 3 (C3), C4, and leptin levels.
|
27870883 |
2016 |
|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, T2D patients with CT/TT rs12979860 HCV risk genotypes possessed significantly higher HbA1c levels than CC carriers (p=0.04).
|
27664841 |
2016 |
|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
TLR2 -174 del variant was associated with TLR2 expression and with specific downstream molecules that drive the expression of different interleukins; rs12979860 Il28B was important in response to interferon-treatment and in spontaneous clearance of HCV.
|
27183918 |
2016 |
|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
This same variant is associated with treatment-induced clearance in patients with genotype 1b, but not 2a. ss469415590 (or rs12979860) genotyping should be considered for patients with HCV genotype 1b and high viral load when making a choice between standard dual therapy and an IFN-free direct-acting antiviral regimen.
|
26820907 |
2016 |
|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Using linear regression, after adjusting for sex, age, infection duration, symptomatic infection, HIV co-infection, interferon-lambda rs12979860 genotype, HCV genotype, and assay run, higher ALT levels (β = 0.20; 95 % CI: 0.07, 0.32; P = 0.002) and HCV RNA levels >400,000 IU/mL (vs. <8,500 IU/mL; β = 0.16; 95 % CI: 0.03, 0.28; P = 0.014) were independently associated with higher IP-10 levels.
|
26911712 |
2016 |
|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this phase 3, randomized, open-label, noninferiority study, 602 patients were randomly assigned (2:1) to daclatasvir vs telaprevir, stratified by IL28B rs12979860 host genotype (CC vs non-CC), cirrhosis status (compensated cirrhosis vs no cirrhosis), and HCV GT1 subtype (GT1a vs GT1b).
|
27022224 |
2016 |
|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
IL28B (rs12979860 and rs8099917) single nucleotide polymorphisms (SNPs) have been recently found among the Pakistani population associated with response to chronic HCV infection INF-α + ribavirin therapy.
|
26177560 |
2015 |
|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms within the interferon lambda (IFN-λ) region are strongly associated with hepatitis C virus (HCV) clearance; the IFNL4-ΔG/TT (rs368234815) polymorphism, which controls the generation of IFN-λ4 protein, is more strongly associated with HCV clearance than rs12979860 (the 'IL28B variant').
|
26186989 |
2015 |
|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Of the 4 interleukin 28B (IL28B) single-nucleotide polymorphisms (SNPs), rs12979860 was the host genetic marker most significantly associated with failure to achieve an SVR in HCV g1-infected individuals [P=3.83×10(-4); odds ratio (OR)=5.61; confidence interval (CI)=2.07-15.18] and gave a positive predictive value for treatment failure of 81.3% for minor homozygotes (TT).
|
25237729 |
2015 |
|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
The IL-28B rs12979860 CC and rs8099917 TT genotypes were proved to be predictor for pegylated-interferon (PEG-IFN)/ribavirin (RBV)-treated hepatitis C virus (HCV) patients.
|
25769643 |
2015 |
|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Multivariate logistic regression of the three markers showed that the A/A genotypes in both rs11506105 (EFGR) and rs11881222 (IL28B), and the C/C genotype in rs12979860 (IL28B) are associated with HCV clearance (recessive model: odds ratio (OR)=2.06, 95% confidence interval (95% CI)=1.09-3.88, P=0.025; OR=2.09, 95% CI=1.23-3.60, P=0.007; and OR=1.95, 95% CI=1.15-3.35, P=0.014 for rs11506105, rs12979860 and rs11881222, respectively).
|
26378651 |
2015 |
|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
IL28B polymorphism (rs12979860) associated with clearance of HCV infection in Poland: systematic review of its prevalence in chronic hepatitis C patients and general population frequency.
|
25712648 |
2015 |
|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
The frequencies of rs12979860 CC type in infected individuals with HCV genotype 1 were 47% and 12% respectively in SVR and non-SVR groups.
|
25958342 |
2015 |
|
rs12979860
|
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Spontaneous HCV clearance was significantly less common in the carriers of the rs8099917 allele G or rs12979860 allele T, while the CT rs12979860_rs8099917 haplotype was more frequent (P = 0.02) in patients showing spontaneous HCV clearance.
|
26658164 |
2015 |