Source: BEFREE

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4680
rs4680
COMT ; MIR4761
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.100 GeneticVariation BEFREE We show that Val/Val but neither Met/Met nor Val/Met carriers of the catechol-O-methyltransferase (COMT) Val(158)Met polymorphism-a prime candidate for anxiety vulnerability-became significantly more anxious during the fMRI experiment (N=97 females: 24 Val/Val, 51 Val/Met, and 22 Met/Met). 25238960

2014
dbSNP: rs4680
rs4680
COMT ; MIR4761
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.100 GeneticVariation BEFREE Analyses suggest that COMT val158met moderates the influence of early life stress on preschool-age symptoms of anxiety. 28859863

2017
dbSNP: rs4680
rs4680
COMT ; MIR4761
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.100 GeneticVariation BEFREE A coding variant in one such gene, encoding the dopamine catabolic enzyme catechol-O-methyltransferase (COMT Val158Met), has previously been associated with anxiety and with anxiety-related temperament and altered neural responses to affective stimuli in healthy individuals. 18729643

2008
dbSNP: rs4680
rs4680
COMT ; MIR4761
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.100 GeneticVariation BEFREE In this population-based study, no clear association between the Val158Met polymorphism and depression and anxiety was revealed. 18578865

2008