|
rs35705950
|
|
Idiopathic Pulmonary Fibrosis
|
|
0.900 |
GeneticVariation
|
BEFREE |
The common gain-of-function MUC5B promoter variant ( rs35705950 ) is the strongest risk factor for the development of idiopathic pulmonary fibrosis (IPF).
|
29565179 |
2018 |
|
rs35705950
|
|
Idiopathic Pulmonary Fibrosis
|
|
0.900 |
GeneticVariation
|
BEFREE |
Four common SNPs (rs3737002, rs2296160, rs1800470, and rs35705950) were observed to be statistically associated with increased risk of IPF.
|
29920840 |
2018 |
|
rs35705950
|
|
Idiopathic Pulmonary Fibrosis
|
|
0.900 |
GeneticVariation
|
BEFREE |
Given the phenotypic similarities between rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) (hereafter, RA-ILD) and idiopathic pulmonary fibrosis, we hypothesized that the strongest risk factor for the development of idiopathic pulmonary fibrosis, the gain-of-function MUC5B promoter variant rs35705950, would also contribute to the risk of ILD among patients with RA.
|
30345907 |
2018 |
|
rs35705950
|
|
Idiopathic Pulmonary Fibrosis
|
|
0.900 |
GeneticVariation
|
BEFREE |
A common gain-of-function MUC5B promoter variant, rs35705950, is the strongest risk factor (genetic and otherwise), accounting for at least 30% of the total risk of developing IPF.
|
30431344 |
2018 |
|
rs35705950
|
|
Idiopathic Pulmonary Fibrosis
|
|
0.900 |
GeneticVariation
|
BEFREE |
<b>Conclusions:</b> A positive feedback bistable ERN2-XBP1S pathway regulates MUC5B-dominated mucus obstruction in IPF, providing an unfolded protein response-dependent mechanism linking the <i>MUC5B</i> promoter rs35705950 polymorphism with IPF pathogenesis.
|
30973754 |
2019 |
|
rs35705950
|
|
Idiopathic Pulmonary Fibrosis
|
|
0.900 |
GeneticVariation
|
BEFREE |
The minor allele of the MUC5B rs35705950 genotype is prevalent in several sporadic forms of ILD, including idiopathic pulmonary fibrosis and chronic hypersensitivity pneumonitis.
|
30660786 |
2019 |
|
rs35705950
|
|
Idiopathic Pulmonary Fibrosis
|
|
0.900 |
GeneticVariation
|
BEFREE |
We tested five single-nucleotide polymorphisms [rs35705950, rs868903 in MUC5B, rs2736100, rs2853676 in TERT and rs1881984 in Telomerase RNA Gene (TERC) and TLs in peripheral blood leucocytes, and evaluated their associations with radiographic extent and survival in IPF.
|
31653936 |
2019 |
|
rs35705950
|
|
Idiopathic Pulmonary Fibrosis
|
|
0.900 |
GeneticVariation
|
BEFREE |
Leukocyte telomere length (LTL), <i>MUC5B</i> rs35705950 and <i>TOLLIP</i> rs5743890 have been associated with idiopathic pulmonary fibrosis (IPF).In this observational cohort study, we assessed the associations between these genomic markers and outcomes of survival and rate of disease progression in patients with interstitial pneumonia with autoimmune features (IPAF, n=250) and connective tissue disease-associated interstitial lung disease (CTD-ILD, n=248).
|
30635297 |
2019 |