|
rs1695
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
A case (n=250)-control (n=500) study was undertaken to investigate the role of Single Nucleotide Polymorphisms (SNP's) in GSTM1 (Present/Null); GSTP1 (Ile105Val), p53 (Arg72Pro), TGFbeta1 (Leu10Pro), c-erbB2 (Ile655Val), and GSTT1 (Null/Present) in breast cancer.
|
18058229 |
2008 |
|
rs1695
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The effect of GSTM1 null/present genotype on the association between GSTP1 Ile105Val and asthma was also investigated.
|
17643058 |
2007 |
|
rs1695
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, our study indicated that the GSTP1 rs1695 A>G polymorphism was correlated with elevated BC risk in Asian women.
|
27323180 |
2016 |
|
rs1695
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms of glutathione S-transferase (GST) genes including GSTT1 positive/null, GSTM1 positive/null, and GSTP1 A313G, and genes for reduced folate carrier 1 G80A (RFC1 G80A), methylenetetrahydrofolate reductase C677T (MTHFR C677T), and breast cancer resistant protein C421A (BCRP C421A) were determined for 26 patients by the polymerase chain reaction (PCR) method or by direct sequencing.
|
17180579 |
2007 |
|
rs1695
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Women homozygous with the T allele in CYP1B1*2 (Ser(119); rs1056827) were at 1.69 (95% confidence interval, 1.17-2.46) times the risk of women homozygous with the G allele; women homozygous with the G allele in GSTP1 (Val(105); rs1695) were at 0.73 (95% confidence interval, 0.54-0.99) times the risk of breast cancer compared with women homozygous with the A allele.
|
19383894 |
2009 |
|
rs1695
|
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
The risk of lung cancer is not strongly associated with the I105V and A114V polymorphisms in the GSTP1 gene or with GSTM3 intron 6 polymorphism.
|
16509765 |
2006 |
|
rs1695
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The polymorphism c.342A>G (p.I105V) in GSTP1 has previously been suggested as a risk factor for asthma.
|
15300848 |
2004 |
|
rs1695
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
For SNP rs1695 in the GSTP1 gene, a correlation with cancer disease stage was observed: a GG genotype is significantly more common in patients with PCa in the 3rd and 4th stage than 1st and 2nd (OR[95%CI] = 2.66[1.15-6.18], p = 0.02).
|
24610081 |
2014 |
|
rs1695
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Glutathione S-transferase P1 (GSTP1) gene Ile105Val polymorphism has been suggested to be involved in the development of cancer.
|
23765758 |
2013 |
|
rs1695
|
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
MDR analysis identified two distinct predictor models for the risk of lung cancer in smokers (tobacco chewing, EPHX1 Tyr113His, and SULT1A1 Arg213His) and non-smokers (CYP1A1*2A, GSTP1 Ile105Val and SULT1A1 Arg213His) with testing balance accuracy (TBA) of 0.6436 and 0.6677 respectively.
|
22206016 |
2011 |
|
rs1695
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, our study indicated that the GSTP1 rs1695 A>G polymorphism was correlated with elevated BC risk in Asian women.
|
27323180 |
2016 |
|
rs1695
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated whether functional GSTP1 (p.Ile105Val-rs1695), NAT2 (590G>A-rs1799930) SNPs and GSTM1 and GSTT1 deletion polymorphisms could modulate the effect of the Mediterranean diet (MD) on BC risk, in Greek-Cypriot women.
|
26572891 |
2017 |
|
rs1695
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
When COMT(LL) was combined with either glutathione S-transferase (GST) M1 null or with GSTP1 Ile-105-Val/Val-105-Val (intermediate/low activity, respectively) genotypes, the risk for developing postmenopausal breast cancer was also significantly increased.
|
9407957 |
1997 |
|
rs1695
|
|
Malignant neoplasm of prostate
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis showed that GSTP1 Ile105Val polymorphism might not be significantly associated with overall prostate cancer risk.
|
23977100 |
2013 |
|
rs1695
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the present case-control study, we investigated the possible association of CYP17 A1A2, GSTP1 ILE105VAL, PON1 Q192R or L55M, and GLO1 A111E polymorphisms with the risk of BC.
|
19379515 |
2009 |
|
rs1695
|
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that GSTP1 Ile105Val polymorphism may increase the risk of lung cancer in the Chinese population.
|
26458582 |
2016 |
|
rs1695
|
|
Prostate carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The glutathione S-transferase (GST) enzymes detoxify several carcinogens and genetic polymorphisms in GSTM1, T1, and P1 (Ile105Val) have been reported to be associated with prostate cancer, mainly from blood samples.
|
17059341 |
2007 |
|
rs1695
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
GSTP1 Ile(105)Val gene polymorphism influences its expression in blood, regardless of cancer disease.
|
21669193 |
2011 |
|
rs1695
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Children carrying GSTP1 rs1138272 or rs1695 minor alleles may constitute a susceptible population at increased risk of asthma associated with air pollution.
|
24465030 |
2014 |
|
rs1695
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
DNA from 143 cases reported to the Industrial Professional Associations (Berufsgenossenschaften) in Germany from 1996 to 2004, who had contracted urothelial cancer due to occupational exposure, and 196 patients from one Department of Surgery in Dortmund, without known malignancy in their medical history, were genotyped using real-time polymerase chain reaction (PCR) (LightCycler) in relation to GSTP1 A1578G (Ile105Val) polymorphism.
|
18569592 |
2008 |
|
rs1695
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the present study, GSTP1Ile105Val (rs1695) polymorphism was related to breast cancer susceptibility or phenotype.
|
26407578 |
2016 |
|
rs1695
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Five SNPs (AHR rs2066853, ATM rs1003623, ESR1 rs2234693, GSTP1 rs1695, and SHBG rs6259) showed generally consistent results in SBCS I and SBCS II and statistically significant associations with breast cancer risk in combined analyses, mostly in subgroups defined by age or menopausal status.
|
21454829 |
2011 |
|
rs1695
|
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
GSTP1 Ile105Val was associated with increased lung function, reduced risk for lung cancer and tobacco-related cancer, and reduced all-cause mortality in the general population.
|
28739440 |
2017 |
|
rs1695
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
Otherwise, the combination of <i>GSTM1</i> entire gene deletion and (GG) genotype of <i>GSTP1</i> polymorphism (rs1695) was significantly associated with BC with p-value <0.05 (i.e. p-value was not significant after correcting for multiple comparison).
|
31571925 |
2019 |
|
rs1695
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found an 86% increase in the OR for breast cancer among carriers of the GSTM1 null, GSTT1 null and GSTP 105Ile/Ile genotypes (OR = 1.86, 95% CI = 1.12, 3.08) and a 36% decrease in the OR among carriers of GSTM1 present, GSTT1 null and GSTP1 105Ile/Val + Val/Val genotypes (OR = 0.64, 95% CI = 0.42, 0.97) compared with GSTM1 present, GSTT1 present and GSTP1 105Ile/Ile carriers.
|
17693660 |
2007 |