|
rs1800871
|
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
After adjusting for age, education, ethnicity, gender, and tobacco smoking, IL10 rs1800871 was inversely associated with oropharyngeal cancer (CT+TT vs. CC adjusted odds ratio [aOR]: 0.69, 95% confidence interval [CI]: 0.50-0.95), and was positively associated with lung cancer among never smokers (TT vs. CT+CC aOR: 2.5, 95% CI: 1.3-5.1) and inversely with oropharyngeal cancer among ever smokers (CT+TT vs. CC aOR: 0.63, 95% CI: 0.41-0.95).
|
20112337 |
2010 |
|
rs3024498
|
|
Helminthiasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Allele C of marker rs3024498 was negatively associated with helminth infection or its markers.
|
23273955 |
2013 |
|
rs1800896
|
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Also, there was significant association of mutant allele and genotypes of IL-10 [-1082 A>G (rs1800896)] with postmenopausal BC.
|
22818022 |
2012 |
|
rs1800896
|
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation
|
BEFREE |
Also, there was significant association of mutant allele and genotypes of IL-10 [-1082 A>G (rs1800896)] with postmenopausal BC.
|
22818022 |
2012 |
|
rs1800872
|
|
Squamous cell carcinoma of oropharynx
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among HPV16(+) patients with SCCOP only, compared to those with the corresponding variant genotypes, the patients with IL-10 rs1800871 and rs1800872 CC genotypes had significantly better survival and ~70-80% reduced risk of death/recurrence after multivariable adjustment.
|
23430974 |
2013 |
|
rs1800896
|
|
Nasopharyngeal carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Among the 15 SNPs detected in the meta-analysis, miR-146a (rs2910164, C>G), HCG9 (rs3869062, A>G), HCG9 (rs16896923, T>C), MMP2 (rs243865, C>T), GABBR1 (rs2076483, T>C), and TP53 (rs1042522, C>G) were associated with decreased susceptibility to NPC, while GSTM1 (+/DEL), IL-10 (rs1800896, A>G), MDM2 (rs2279744, T>G), MDS1-EVI1 (rs6774494, G>A), XPC (rs2228000, C>T), HLA-F (rs3129055, T>C), SPLUNC1 (rs2752903, T>C; and rs750064, A>G), and GABBR1 (rs29232, G>A) were associated with increased susceptibility to NPC.
|
28881764 |
2017 |
|
rs1800872
|
|
Pemphigus Vulgaris
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among the large number of studied SNPs, it was found that several SNPs in different genes might control the susceptibility of PV, including TNFA (rs361525, rs1800629, rs1800629), IL10 (rs1800871, rs1800896, rs1800871, and rs1800872), IL6 (rs1800795), CTLA4 (rs231775), ICOS (rs10932029), CD86 (rs1129055), DSG3 (rs8085532, rs3911655, rs3848485, rs3794925, rs1466379), ST18 (rs2304365, rs17315309) and TAP2 (rs7454108), probably in a population-specific manner.
|
31342641 |
2020 |
|
rs1800872
|
|
Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among three investigated SNPs, rs1800872 was observed to be significantly associated with risk of SZ (AA vs. AC+CC, Pooled OR = 1.351, P-value = 2.06E-04).
|
24603720 |
2014 |
|
rs3024493
|
|
Ulcerative Colitis
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
rs3024493
|
|
Psoriasis
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
rs3024493
|
|
Crohn Disease
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
rs3024493
|
|
Ankylosing spondylitis
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
rs3024493
|
|
Cholangitis, Sclerosing
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
rs3024498
|
|
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation
|
BEFREE |
And, there was significant difference in allele frequency at rs3024498 between SLE patients with and without anti-double-stranded DNA (P=0.032).
|
29199038 |
2018 |
|
rs1800871
|
|
Diabetic Nephropathy
|
|
0.020 |
GeneticVariation
|
BEFREE |
As for complications in DM, significant association with the risk of diabetic nephropathy (DN) was detected for the rs1800871 polymorphism.
|
30223288 |
2018 |
|
rs3024493
|
|
Inflammatory Bowel Diseases
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
|
rs1800896
|
|
Dermatitis, Atopic
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association between the IL10 -1082A>G (rs1800896) single-nucleotide polymorphism and atopic dermatitis: a systematic review and meta-analysis.
|
23857017 |
2014 |
|
rs1800896
|
|
Eczema
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association between the IL10 -1082A>G (rs1800896) single-nucleotide polymorphism and atopic dermatitis: a systematic review and meta-analysis.
|
23857017 |
2014 |
|
rs1800871
|
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Association of IL-10 rs1800871 and rs1800872 Polymorphisms with Breast Cancer Risk: A Systematic Review and Meta-Analysis
|
30583340 |
2018 |
|
rs1800871
|
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation
|
BEFREE |
Association of IL-10 rs1800871 and rs1800872 Polymorphisms with Breast Cancer Risk: A Systematic Review and Meta-Analysis
|
30583340 |
2018 |
|
rs1800872
|
|
Coronary heart disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of IL-8-251 A/T rs4073 and IL-10 rs1800872 -592C/A Polymorphisms and Coronary Artery Disease in North Indian Population.
|
30073578 |
2019 |
|
rs1800872
|
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of IL-8-251 A/T rs4073 and IL-10 rs1800872 -592C/A Polymorphisms and Coronary Artery Disease in North Indian Population.
|
30073578 |
2019 |
|
rs1800872
|
|
Coronary Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of IL-8-251 A/T rs4073 and IL-10 rs1800872 -592C/A Polymorphisms and Coronary Artery Disease in North Indian Population.
|
30073578 |
2019 |
|
rs3024496
|
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
Associations of IL10 haplotypes with prostate cancer were explained by high linkage disequilibrium between two tagSNPs (rs1800890 and rs3024496) and -1082G>A.
|
19267370 |
2009 |
|
rs3024496
|
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Associations of IL10 haplotypes with prostate cancer were explained by high linkage disequilibrium between two tagSNPs (rs1800890 and rs3024496) and -1082G>A.
|
19267370 |
2009 |