Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 GeneticVariation disease BEFREE We analyzed RNA-Seq data from parietal lobe brain tissue from AD cases with TREM2 variants (n = 33), AD cases (n = 195) and healthy controls (n = 118), from three independent datasets using Kallisto and the R package tximport to determine the read count for each transcript and quantified transcript abundance as transcripts per million. 31068200 2019
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 AlteredExpression disease BEFREE Our studies provide a first glimpse into the boost in myeloid cell function that can be achieved by pharmacological modulation of TREM2 activity that can potentially be ameliorative in neurodegenerative diseases such as Alzheimer's disease. 29599291 2018
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 GeneticVariation disease BEFREE More evidence for association of a rare TREM2 mutation (R47H) with Alzheimer's disease risk. 26058841 2015
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 GeneticVariation disease BEFREE Interestingly, recent evidence-associated rare genetic variants of TREM2 gene with increased risk of Alzheimer's disease, frontotemporal dementia, amyotrophic lateral sclerosis, and Parkinson's disease. 28214109 2017
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 Biomarker disease BEFREE In this review, we summarize increases in our understanding of the involvement of TREM2 and microglia in AD development that may open new therapeutic strategies targeting the immune system to influence AD pathogenesis. 30572908 2018
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 GeneticVariation disease BEFREE Coding variants in TREM2 increase risk for Alzheimer's disease. 24899047 2014
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 GeneticVariation disease BEFREE TREM2 rare protein coding genetic variants have been linked to AD. 29685286 2018
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 Biomarker disease BEFREE Inflammatory processes involving TREM2 may occur in schizophrenia, as observed in neurocognitive disorders such as AD. 26332043 2015
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 GeneticVariation disease BEFREE Notably, loss-of-function mutations of either <i>DAP12</i> or <i>TREM2</i> result in a disorder known as Nasu-Hakola disease (NHD); and mutations of these genes have been associated with the risk for Alzheimer's disease (AD), suggesting that TREM2 and DAP12 may regulate common signaling pathways in the disease pathogenesis. 28680398 2017
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 Biomarker disease BEFREE Thus, TREM2 enables microglial responses during AD by sustaining cellular energetic and biosynthetic metabolism. 28802038 2017
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 Biomarker disease BEFREE (2019) demonstrate opposing effects of CD33 and TREM2 on AD phenotypes, where CD33 deletion promotes neuroprotection in a manner dependent on TREM2. 31487521 2019
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 Biomarker disease BEFREE Thus, TREM2 protects from AD by enabling microglia to surround and alter Aβ plaque structure, thereby limiting neuritic damage. 27091843 2016
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 GeneticVariation disease BEFREE A rare TREM2 missense mutation (rs75932628-T) was reported to confer a significant Alzheimer's disease (AD) risk. 26365049 2016
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 GeneticVariation disease BEFREE Rare variants in TREM2 were reported to be associated with significant Alzheimer's disease (AD) risk. 27769848 2016
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 Biomarker disease BEFREE Down-regulated mRNAs include those encoding complement factor-H (CFH), an SH3-proline-rich multi-domain-scaffolding protein of the postsynaptic density (SHANK3), and the triggering receptor expressed in myeloid/microglial cells (TREM2), as is observed in sporadic AD brain. 29637444 2018
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 Biomarker disease BEFREE TREM2 plays a critical role in microglial activation, survival, and phagocytosis; however, the pathophysiological role of sTREM2 in AD is not well understood. 31413141 2019
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 GeneticVariation disease BEFREE TREM2 variants associated with Alzheimer's disease induce partial loss of function of the TREM2 protein and alter the behaviour of microglial cells, including their response to amyloid plaques. 30033062 2018
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 GeneticVariation disease BEFREE Two variants in SORL1 and TREM2 were identified that were associated with Alzheimer's disease. 31217084 2020
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 GeneticVariation disease BEFREE Moreover, the rare TREM2 variant (p.Arg47His), which was considered to be a risk factor for Alzheimer's disease in European descent populations, was not detected in our cohort. 29723869 2018
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 GeneticVariation disease BEFREE Our data corroborate and extend previous findings to include an increased frequency of rare heterozygous TREM2 variations in AD and FTD, and show that TREM2 variants may play a role in neurodegenerative diseases in general. 24119542 2014
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 AlteredExpression disease BEFREE TREM2 mRNA levels were significantly higher in AD compared to controls and aMCI. 28453482 2017
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 Biomarker disease BEFREE These findings indicate that TREM2-mediated protection in AD is at least partially dependent on the reservation of microglial phagocytic functions, emphasizing the importance of early therapeutic interventions for this devastating disease. 26780455 2017
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 GeneticVariation disease BEFREE A cross-sectional study of 1027 participants of the Alzheimer's Disease Imaging Initiative (ADNI) cohort, including 43 subjects carrying TREM2 rare genetic variants, was conducted to measure CSF sTREM2 using a previously validated enzyme-linked immunosorbent assay (ELISA). 30630532 2019
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 GeneticVariation disease BEFREE Our 3.1 Å TREM2 crystal structure revealed that mutations found in Nasu-Hakola disease are buried whereas Alzheimer's disease risk variants are found on the surface, suggesting that these mutations have distinct effects on TREM2 function. 27995897 2016
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 AlteredExpression disease BEFREE Quantitative analysis of TREM2 protein confirmed qPCR results that showed higher levels in AD than in control brains. 27887626 2016