×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
0.500
CausalMutation
disease
CLINVAR
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
0.500
GeneticVariation
disease
BEFREE
Our results suggest that the IRF5 functional polymorphisms analyzed do not seem to be implicated in genetic susceptibility to RA .
17133578
2006
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
0.500
GeneticVariation
disease
LHGDN
Analysis of IRF5 gene functional polymorphisms in rheumatoid arthritis.
17133578
2006
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
0.500
GeneticVariation
disease
LHGDN
IRF5 rs2004640-T allele, the new genetic factor for systemic lupus erythematosus, is not associated with rheumatoid arthritis.
17158136
2007
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
0.500
GeneticVariation
disease
BEFREE
Our results exclude the IRF5 rs2004640 -T allele as a major genetic factor for RA in this French Caucasian population.
17158136
2007
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
0.500
GeneticVariation
disease
LHGDN
Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis.
17599733
2007
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
0.500
GeneticVariation
disease
BEFREE
Given the fact that anti-CCP-negative RA differs from anti-CCP-positive RA with respect to genetic and environmental risk factor profiles, our results indicate that genetic variants of IRF5 contribute to a unique disease etiology and pathogenesis in anti-CCP-negative RA .
17599733
2007
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
0.500
Biomarker
disease
BEFREE
The IRF5 gene has been shown to be associated with systemic lupus erythematosus and rheumatoid arthritis .
17881657
2007
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
0.500
Biomarker
disease
BEFREE
Interestingly, recent studies have not found association of IRF5 with the other autoimmune diseases, such as rheumatoid arthritis or psoriasis, suggesting the unique role for IRF5 in the development of lupus.
18075793
2007
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
0.500
Biomarker
disease
BEFREE
Previously, IRF5 has been found to be associated with systemic lupus erythematosus, rheumatoid arthritis and inflammatory bowel diseases.
18285424
2008
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
0.500
Biomarker
disease
BEFREE
Here, we assessed the genetic role of IRF5 in susceptibility to rheumatoid arthritis (RA ) in Japanese subjects.
18408250
2009
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
0.500
GeneticVariation
disease
BEFREE
All of the remaining RA patients (ACPA- or SE+) showed a strong association with IRF5 SNPs, which followed a complex pattern of opposing effects mediated by independent haplotypes.
18438842
2008
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
0.500
GeneticVariation
disease
BEFREE
Our results indicate that the TT genotype of the IRF5 (rs2004640 ) dimorphism is associated with RA in a Tunisian population.
18752149
2008
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
0.500
GeneticVariation
disease
LHGDN
Association of IRF5 gene polymorphisms with rheumatoid arthritis in a Tunisian population.
18752149
2008
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
0.500
GeneticVariation
disease
LHGDN
Putative role of functional interferon regulatory factor 5 (IRF5) polymorphism in rheumatoid arthritis in a Korean population.
18843785
2008
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
0.500
GeneticVariation
disease
BEFREE
Two of the IRF5 polymorphisms, CGGGGindel (OR 1.38, 95% CI 1.09-1.76, pcorr = 0.04) and rs2004640 (OR 1.36, 95% CI 1.09-1.68, pcorr = 0.03), and one haplotype, including the rs2004640 and the CGGGGindel, ht3 (A-Del-T-C-del-A-T) (OR 1.39, 95% CI 1.09-1.79, pcorr = 0.04) were significantly associated with an increased risk of RA .
18843785
2008
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
0.500
GeneticVariation
disease
BEFREE
Our metaanalysis supported the evidence of the significant role of IRF5 polymorphisms in RA .
19228650
2009
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
0.500
GeneticVariation
disease
BEFREE
The strongest association was detected for a functionally relevant four SNP haplotype of IRF5 , which comprised a protective effect (p = 0.0000897, p (corrected) = 0.0012, OR 0.73, 95% CI 0.62-0.85) similar to those previously seen in RA and SLE.
20049410
2010
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
0.500
Biomarker
disease
BEFREE
TNFAIP3, similar to STAT4 and IRF5 , may be a common genetic risk factor for SLE and RA that is shared between the Caucasian and Japanese populations.
20112363
2010
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
0.500
Biomarker
disease
CTD_human
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
20453842
2010
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
0.500
Biomarker
disease
BEFREE
Multivariate logistic regression analysis found IRF5 linked to RA independently of the rheumatoid factor status.
20980283
2011
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
0.500
GeneticVariation
disease
GWASDB
A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.
21156761
2011
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
0.500
GeneticVariation
disease
GWASCAT
A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.
21156761
2011
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
0.500
GeneticVariation
disease
BEFREE
Polymorphisms in the IRF5 gene have been associated with susceptibility to autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis .
21239750
2011
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
0.500
GeneticVariation
disease
BEFREE
Two interferon regulatory factor 5 (IRF5 ) gene variants were examined for association with rheumatoid arthritis (RA ).
21807777
2011