|
TNFSF13B
|
0.100 |
Biomarker
|
group |
BEFREE |
The Fc-fusion protein atacicept is currently under clinical investigation for its biotherapeutic application in autoimmune diseases owing to its ability to bind the two cytokines B-Lymphocyte Stimulator (BLyS) and A PRoliferation-Inducing Ligand (APRIL).
|
31349756 |
2020 |
|
TNFSF13B
|
0.100 |
Biomarker
|
group |
BEFREE |
Development of tibulizumab, a tetravalent bispecific antibody targeting BAFF and IL-17A for the treatment of autoimmune disease.
|
31181988 |
2020 |
|
TNFSF13B
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently, It has been suggested that BAFF might be a potential therapeutic target for treating autoimmune disease.
|
31156628 |
2019 |
|
TNFSF13B
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The genes harboring these mutations, including DGKI, TNFRSF10A, GNGT1, CPAMD8, and BAFF, which are expressed in both eye and brain tissues and/or are related to autoimmune diseases, provide new avenues to evaluate the inherited causes of these devastating autoimmune conditions.
|
31161422 |
2019 |
|
TNFSF13B
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This cytokine is encoded on TNFSF13B gene, and diverse single-nucleotide polymorphisms have been associated with susceptibility in different autoimmune disorders.
|
30747361 |
2019 |
|
TNFSF13B
|
0.100 |
AlteredExpression
|
group |
BEFREE |
It is possible that the overexpression of BAFF and APRIL contributes to the pathogenesis of autoimmune diseases.
|
30941763 |
2019 |
|
TNFSF13B
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These data suggest the inhibitory effects of GYF-21 on the survival, activation, proliferation, and differentiation of B cells mainly via blocking BAFF activated signaling pathways, and its potential to be developed into therapeutic drug for autoimmune diseases, especially systemic lupus erythematosus (SLE).
|
30597293 |
2019 |
|
TNFSF13B
|
0.100 |
Biomarker
|
group |
BEFREE |
BAFF affects physiological T-cell activation through BAFF-R-mediated activation of the PI3K-Akt signaling pathway which mirrors one of the pathological mechanisms of T cell-mediated autoimmune diseases.
|
30921706 |
2019 |
|
TNFSF13B
|
0.100 |
Biomarker
|
group |
BEFREE |
The two related tumor necrosis factor members a proliferation-inducing ligand (APRIL) and B-cell activation factor (BAFF) are currently targeted in autoimmune diseases as B-cell regulators.
|
30635946 |
2019 |
|
TNFSF13B
|
0.100 |
Biomarker
|
group |
BEFREE |
We also generated AMG 570, an ICOSL and BAFF bispecific inhibitory molecule, for potential treatment of autoimmune diseases such as SLE.
|
30789152 |
2019 |
|
TNFSF13B
|
0.100 |
Biomarker
|
group |
BEFREE |
Further, the significant and independent negative association between testosterone levels and BAFF would suggest a link between androgen deficiency and autoimmunity observed in SCI via modulation of BAFF and B cell numbers.
|
31020912 |
2019 |
|
TNFSF13B
|
0.100 |
Biomarker
|
group |
BEFREE |
Associations of BAFF with Th2 profile cytokines and disease activity, as well as APRIL with Th1 profile cytokines and organ damage, suggest that BAFF and APRIL generated in the autoimmunity context could through still unknown mechanisms, modulate the microenvironment, and perpetuate the inflammatory response, autoantibody production and organ damage observed in SLE patients.
|
30467093 |
2019 |
|
TNFSF13B
|
0.100 |
Biomarker
|
group |
BEFREE |
The B cell survival factor (TNFSF13B/BAFF) is often elevated in autoimmune diseases and is targeted in the clinic for the treatment of systemic lupus erythematosus.
|
29572442 |
2018 |
|
TNFSF13B
|
0.100 |
Biomarker
|
group |
BEFREE |
Our data thus provides insights for the design of new drugs targeting BAFF for the treatment of autoimmune diseases.
|
29572471 |
2018 |
|
TNFSF13B
|
0.100 |
Biomarker
|
group |
BEFREE |
Together, these findings highlight how multiple signaling pathways integrate to promote class-switched autoAb production by transitional B cells, events that likely impact the pathogenesis of SLE and other BAFF-dependent autoimmune diseases.
|
30373855 |
2018 |
|
TNFSF13B
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Accordingly, individuals bearing the TNFSF13B variant had higher circulating BAFF and elevated risk of developing autoimmune diseases.
|
30272251 |
2018 |
|
TNFSF13B
|
0.100 |
Biomarker
|
group |
BEFREE |
We treated BAFF transgenic (BAFFtg) mice, a model of AID in which immunisation against biologic drugs is high, with different TNFi.
|
29936438 |
2018 |
|
TNFSF13B
|
0.100 |
Biomarker
|
group |
BEFREE |
Our study uncovers a previously unrecognized regulation of BAFF by testosterone and raises important questions about BAFF in testosterone-mediated protection against autoimmunity.
|
29802242 |
2018 |
|
TNFSF13B
|
0.100 |
GeneticVariation
|
group |
BEFREE |
An insertion-deletion variant (GCTGT→A) of this gene, leading to increased levels of BAFF, has been recently implicated in the genetic predisposition to several autoimmune diseases, including multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis.
|
30586461 |
2018 |
|
TNFSF13B
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We describe a recently identified genetic variant localized in the 3'UTR of the TNFSF13B gene, associated with autoimmunity risk and responsible of an increased stability and translation of TNFSF13B mRNA.
|
29582564 |
2018 |
|
TNFSF13B
|
0.100 |
Biomarker
|
group |
BEFREE |
We showed that BAFF could induce IL-35 production by a unique CD5<sup>+</sup>CD1d<sup>hi</sup>FcγRIIb<sup>hi</sup> regulatory B-cell subset mainly through TACI activation in lupus, providing an advanced understanding of the regulatory effect of BAFF in autoimmune diseases.
|
28844943 |
2017 |
|
TNFSF13B
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These results suggest that CA suppresses BAFF expression by inhibiting NF-κB activity, and CA may serve as a novel therapeutic agent to down-regulate excessive BAFF expression in autoimmune diseases.
|
28122293 |
2017 |
|
TNFSF13B
|
0.100 |
Biomarker
|
group |
BEFREE |
In this review, we discuss the rationale for dual BAFF/APRIL inhibition versus single BAFF inhibition in autoimmune disease, by focusing on the similarities and differences between the physiological and pathogenic roles of the two molecules.
|
28215100 |
2017 |
|
TNFSF13B
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, if this B cell-produced BAFF proves to be actively regulating this same B cell subset, our findings point to an ancient mechanism to control B cell differentiation and survival in lower vertebrates, which has been silenced in mammals in physiological conditions, but reemerges under pathological conditions, such as B cell lymphomas and autoimmune diseases.
|
28360916 |
2017 |
|
TNFSF13B
|
0.100 |
Biomarker
|
group |
BEFREE |
B cell activating factor (BAFF) regulates B cell maturation, survival, function, and plays a critical pathogenic role in autoimmune diseases.
|
28199852 |
2017 |