| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | Biomarker | group | BEFREE | Thus, early events in thymic T cell development and repertoire generation are abnormal in type 1 diabetes, which suggest that short CDR3s increase the potential for self-recognition, conferring heightened risk of autoimmune disease. | 29176645 | 2017 | ||||
|
0.070 | GeneticVariation | group | BEFREE | Patients with atypical presentations of RAG or IL2RG mutations associated with autoimmunity and granulomatous disease did not have altered overall diversity but instead had skewed V-J pairing and skewed CDR3 amino acid use. | 24406074 | 2014 | ||||
|
0.070 | GeneticVariation | group | BEFREE | In this study, we apply high-throughput next-generation sequencing to T cells from both a healthy cohort and a cohort with an autoimmune disease (multiple sclerosis) to identify sequence features in the variable CDR3 region of the rearranged T cell receptor gene that distinguish CD4+ from CD8+ T cells. | 23428915 | 2013 | ||||
|
0.070 | Biomarker | group | BEFREE | The CDR3 regions from T cell isolates showed sequence homology to those in humans with anti-RNP autoimmunity. | 20797908 | 2010 | ||||
|
0.070 | GeneticVariation | group | BEFREE | Fas-L+ TCR BV8+ T cells revealed the conserved amino acids motif in the CDR3 region, suggesting that Fas-L+ T cells might expand by antigen stimulation and play a crucial role as Th0-type T cells in triggering autoimmunity in rheumatoid synovium. | 10685790 | 2000 | ||||
|
0.070 | Biomarker | group | BEFREE | Thus, CDR3 spectratyping using PBL can be used for diagnosis and assessment of T cell-mediated autoimmune diseases and is applicable to human autoimmune diseases. | 9754562 | 1998 | ||||
|
0.070 | Biomarker | group | BEFREE | We sought definitive evidence of an antigen-driven B cell response (i.e., clones derived from the same VH, DH, and JH gene segments with shared somatic mutations) in RA synovial mRNA transcripts, and to characterize CDR3 intervals at the target of inflammation in this autoimmune disease. | 9606177 | 1998 |