Evidence for genetic association exists between a cubilin and a rare megalin variant with diabetes-associated ESRD in populations with recent African ancestry.
The CUBN allele effects on ACR were twice as strong in people with diabetes - a result robust to an optimization-algorithm approach to simulating interactions, validating previously reported gene-diabetes interactions (P≤4x10-5).
The current study identifies a rare coding variant in the CUBN locus and other potential genes associated with albuminuria in individuals with and without diabetes.