Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
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0.380 | Biomarker | group | BEFREE | BMI >45 kg/m<sup>2</sup> was associated with higher prevalence of hypertension, systolic and diastolic blood pressure, C-reactive protein, waist circumference, body fat % and family history of heart diseases, enhancing the risk for the occurrence of cardiovascular diseases. | 31791637 | 2020 | ||||
|
0.380 | AlteredExpression | group | BEFREE | Prognosis of myocardial infarction tends to be worse when serum C-reactive protein (CRP) level is high. miRNAs are also known to be involved in different pathogeneses of heart diseases such as myocardial infarction. | 31063484 | 2019 | ||||
|
0.380 | Biomarker | group | BEFREE | The rich expression of antimicrobial peptides and its association with CRP support the idea that an inflammatory process is involved in the pathogenesis of acquired heart diseases. | 30734265 | 2019 | ||||
|
0.380 | Biomarker | group | BEFREE | Statins have antiinflammatory effects and are known to decrease risk of cardiovascular events and to reduce serum levels of C-reactive protein (CRP), a widely studied biomarker and potential mediator of inflammation and heart disease. | 24410968 | 2014 | ||||
|
0.380 | GeneticVariation | group | BEFREE | Genetic predisposition to high baseline CRP might account for a high risk of heart diseases. | 22828776 | 2012 | ||||
|
0.380 | Biomarker | group | BEFREE | C-reactive protein promotes cardiac fibrosis and inflammation in angiotensin II-induced hypertensive cardiac disease. | 20157054 | 2010 | ||||
|
0.380 | Biomarker | group | CTD_human | Elevation of C-reactive protein (CRP) levels in blood was recognized as one of the cardiac disease risk factors. | 17388968 | 2007 | ||||
|
0.380 | Biomarker | group | BEFREE | The basic mechanisms responsible for this association are not clear; CRP may merely be a marker of inflammation with no specific role in the pathogenesis of cardiac disease or may directly modulate the disease process. | 12237169 | 2002 | ||||
|
0.380 | GeneticVariation | group | BEFREE | Elevation of baseline C-reactive protein (CRP) is associated with increased risk of cardiac disease. | 11857055 | 2002 |