|
SERPINE1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Insulin increased PAI-1 promoter activity, PAI-1 mRNA, and accumulation of PAI-1 protein in the conditioned media.
|
20299979 |
2010 |
|
SERPINE1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Treatment of cells with insulin increased PAI-1 gene expression, and this effect was abolished by Ad-CA-FoxO1.
|
19563779 |
2009 |
|
SERPINE1
|
0.100 |
Biomarker
|
disease |
BEFREE |
A transient transfection assay of the human PAI-1 promoter-luciferase construct demonstrated that insulin increased PAI-1 promoter activity.
|
18607173 |
2008 |
|
SERPINE1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Positive correlations between PAI-1 and waist circumference and BMI, and negative correlations between BMI and antioxidative defense in the pre-metabolic syndrome patients show that this early stage preceding the metabolic syndrome is also characterized by atherosclerotic complication risks and evident hyperinsulinism and insulin resistance.
|
17848118 |
2007 |
|
SERPINE1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Enhanced levels of plasminogen activator inhibitor-1 (PAI-1) are considered to be a risk factor for pathological conditions associated with hypoxia or hyperinsulinemia.
|
17384280 |
2006 |
|
SERPINE1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Consistently across ethnic groups, increased PAI-1 protein levels were associated with increased insulin resistance and overall and central obesity (p value < 0.0001, combined sample).
|
15297806 |
2004 |
|
SERPINE1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, increased plasma PAI-1 levels are associated with dyslipidemia, hyperinsulinemia and hypertension.
|
10867719 |
2000 |
|
SERPINE1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PAI-1 mRNA levels decreased in the three groups during a 240-min euglycemic hyperinsulinemic clamp (P<0.05 for all groups), and a similar reduction was observed during a 240-min saline control study indicating that adipose tissue PAI-1 gene expression has diurnal variation and is not acutely controlled by hyperinsulinemia.
|
11025560 |
2000 |
|
SERPINE1
|
0.100 |
Biomarker
|
disease |
BEFREE |
These in vitro studies with the 1/1 PAI-1 genotyped cultured HUVECs, suggests that hyperinsulinemia may be expected to increase EC PAI-1 synthesis in those patients with the responsive 1/1 genotype.
|
10595645 |
1999 |
|
SERPINE1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hep G2 cells may be a suitable model to study PAI-1 regulation in response to hyperinsulinemia.
|
8387542 |
1993 |