| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | An inverse correlation in expression levels was seen between miR-17/92 and both CDKN1A and PTEN in two cohorts of CLL patients. | 29367757 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | Therapeutic inhibition of USP7-PTEN network in chronic lymphocytic leukemia: a strategy to overcome TP53 mutated/deleted clones. | 28418900 | 2017 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | These findings support miR-26a and miR-214 down-regulate expression of PTEN in CLL, but not PTEN mutation or promoter methylation. | 25361012 | 2015 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Low expression level of phosphatase and tensin homolog deleted on chromosome ten predicts poor prognosis in chronic lymphocytic leukemia. | 23013295 | 2013 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | CLL cell death upon CK2 inhibition is mediated by inactivation of PKC, a PI3K downstream target, and correlates with increased PTEN activity, indicating that CK2 promotes CLL cell survival at least in part via PI3K-dependent signaling. | 20660292 | 2010 | ||||
|
0.080 | Biomarker | disease | BEFREE | The overexpression of microRNA-21 (miR-21) is linked to a number of human tumors including colorectal cancer, where it appears to regulate the expression of tumor suppressor genes including p21, phosphatase and tensin homolog, TGFβ receptor II, and B-cell leukemia/lymphoma 2 -associated X protein. | 21078976 | 2010 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Induction of B-chronic lymphocytic leukemia cell apoptosis by arsenic trioxide involves suppression of the phosphoinositide 3-kinase/Akt survival pathway via c-jun-NH2 terminal kinase activation and PTEN upregulation. | 20534739 | 2010 | ||||
|
0.080 | Biomarker | disease | BEFREE | Nevertheless, PTEN protein may be absent in B-CLL with a normal PTEN genotype, suggesting a role of this phosphatase in the molecular pathology of B-CLL. | 12670337 | 2003 |