Furthermore, a decreased risk of chronic lymphocytic leukemia (CLL) was associated with the ABCG2rs2231142 variant (p = 0.0004), which could be replicated in an independent population.
To assess whether the poor prognosis of ZAP70-positive B-cell chronic lymphocytic leukemia (CLL) is associated with the overexpression of ABC transporter genes that are responsible for pleiotropic drug resistance.