Gene: TNFAIP3 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3 		0.700 GeneticVariation disease BEFREE TNFAIP3, an RA candidate gene, flanks this region, and polymorphisms in both the TNFAIP3 gene and the intergenic region are associated with systemic lupus erythematosus. 19292917 2009
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3 		0.700 Biomarker disease BEFREE TNFAIP3, similar to STAT4 and IRF5, may be a common genetic risk factor for SLE and RA that is shared between the Caucasian and Japanese populations. 20112363 2010
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3 		0.700 GeneticVariation disease BEFREE TNFAIP3 gene polymorphisms associated with differential susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Korean population. 24489017 2014
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3 		0.700 Biomarker disease BEFREE TNFAIP3 is a ubiquitin-editing enzyme that negatively regulates multiple NF-κB signaling pathways and dysregulation of TNFAIP3 is related to systemic lupus erythematosus (SLE). 26110642 2015
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3 		0.700 AlteredExpression disease BEFREE TNFAIP3 mRNA was significantly downregulated in the CD4 + T cells of SLE patients compared with NCs. 28158872 2017
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3 		0.700 GeneticVariation disease BEFREE A de novo frameshift mutation in TNFAIP3 was found in the NPSLE patient. 31625129 2019
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3 		0.700 GeneticVariation disease GWASCAT A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. 19838195 2009
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3 		0.700 SusceptibilityMutation disease ORPHANET An enhancer element harboring variants associated with systemic lupus erythematosus engages the TNFAIP3 promoter to influence A20 expression. 24039598 2013
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3 		0.700 GeneticVariation disease BEFREE An enhancer element harboring variants associated with systemic lupus erythematosus engages the TNFAIP3 promoter to influence A20 expression. 24039598 2013
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3 		0.700 GeneticVariation disease BEFREE As proof of concept, we employed TALEN (transcription activation-like effector nuclease)-mediated genome editing to specifically disrupt the TT>A enhancer region to mimic candidate causal variants identified in the systemic lupus erythematosus-associated susceptibility gene, tumor necrosis factor-α-induced protein 3 (TNFAIP3), in an isogenic HEK293T cell line devoid of other linkage disequilibrium-associated variants. 26821284 2016
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3 		0.700 GeneticVariation disease BEFREE Association of TNFAIP3 and TNIP1 polymorphisms with systemic lupus erythematosus risk: A meta-analysis. 29783072 2018
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3 		0.700 GeneticVariation disease BEFREE Associations between TNFAIP3 gene polymorphisms and systemic lupus erythematosus: a meta-analysis. 22924496 2012
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3 		0.700 GeneticVariation disease BEFREE Associations between TNFAIP3 gene polymorphisms and systemic lupus erythematosus risk: an updated meta-analysis. 27726311 2016
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3 		0.700 Biomarker disease BEFREE C/EBP β/TNFAIP3/TNIP1 is associated with SLE activity. 27659348 2017
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3 		0.700 GeneticVariation disease BEFREE For TNFAIP3, we first demonstrated that a low-frequency variant, rs117480515, tagged the recently identified TT>A SLE dinucleotide. 22488580 2012
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3 		0.700 Biomarker disease BEFREE Genetic variants in the genes Tnip1 and TNFAIP3 are both strongly associated with susceptibility to autoimmune chronic inflammatory diseases such as psoriasis vulgaris and systemic lupus erythematosus (SLE) in humans. 30341420 2019
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3 		0.700 SusceptibilityMutation disease ORPHANET Genetics and epigenetics of systemic lupus erythematosus. 23943494 2013
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3 		0.700 GeneticVariation disease GWASCAT Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus. 27399966 2016
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3 		0.700 Biomarker disease CTD_human Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. 19838193 2009
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3 		0.700 GeneticVariation disease GWASDB Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. 19838193 2009
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3 		0.700 GeneticVariation disease GWASCAT Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. 19838193 2009
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3 		0.700 GeneticVariation disease BEFREE However, IRF5 and TNFAIP3 gene alleles, established risk factors for SLE in populations of European and Asian ancestry, are not significantly associated with SLE in this cohort. 31032751 2019
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3 		0.700 GeneticVariation disease GWASCAT Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans. 26663301 2016
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3 		0.700 Biomarker disease BEFREE In conclusion, our data suggest that TNFAIP3 is a susceptible gene for SLE in the Han Chinese population. 26846592 2016
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3 		0.700 GeneticVariation disease BEFREE In conclusion, single nucleotide polymorphisms in ITGAM, TNFSF4, TNFAIP3 and STAT4 genes are associated with susceptibility to SLE in a North Indian population. 30041578 2018