| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | AlteredExpression | disease | BEFREE | Elevated bacterial burden with malaria induces the expression of TLR-2 and TLR-4 triggering intense inflammatory response (NFκB, Th1/Th2 cytokines) in coinfected mice. | 29394238 | 2018 | ||||
|
0.070 | Biomarker | disease | BEFREE | We show that administration of PEG-Pam<sub>2</sub>Cys, a soluble form of the TLR2 agonist S-[2,3-bis(palmitoyloxy)propyl] cysteine (Pam<sub>2</sub>Cys), significantly and dramatically reduces the numbers of malaria parasites that grow in the livers of mice following subsequent challenge with sporozoites. | 30396012 | 2018 | ||||
|
0.070 | Biomarker | disease | BEFREE | In this study, we demonstrate that initial stimulation with <i>Plasmodium falciparum</i>-infected RBCs or the malaria crystal hemozoin induced human adherent PBMCs to hyperrespond to subsequent ligation of TLR2. | 29330325 | 2018 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | Toll like receptor 2 and 4 polymorphisms in malaria endemic populations of India. | 23200752 | 2013 | ||||
|
0.070 | Biomarker | disease | BEFREE | Examples include variants of TLR4 in sepsis, malaria, inflammatory bowel disease and atherosclerosis; variants in TLR2 in tuberculosis and asthma; a variant in Mal (a key signal for TLR2 and TLR4) in malaria, tuberculosis and systemic lupus erythematosus; and variants in the kinase IRAK4 in pyogenic infections. | 20375592 | 2009 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | A post-PCR Ligation Detection Reaction-Fluorescent Microsphere Assay (LDR-FMA) was developed to determine the frequencies of TLR2, TLR4, TLR9, MyD88-Adaptor Like Protein (MAL) single nucleotide polymorphisms (SNPs), and TLR2 length polymorphisms in 170 residents of two regions of Kenya where malaria transmission is stable and high (holoendemic) or episodic and low, 346 residents of a malaria holoendemic region of Papua New Guinea, and 261 residents of North America of self-identified ethnicity. | 19317913 | 2009 | ||||
|
0.070 | AlteredExpression | disease | LHGDN | A significant decrease in the percentage of circulating CD14(+)monocytes and MDCs expressing TLR2 was found in both severe and mild malaria patients. | 17854755 | 2008 |