Taken together, our results indicate a role for the novel DDX3-CBC-eIF3 translational complex in promoting metastasis.<b>Significance:</b> The discovery of DDX3-mediated expression of oncogenic uORF-containing genes expands knowledge on translational control mechanisms and provides potential targets for cancer therapy.<b>Graphical Abstract:</b> http://cancerres.aacrjournals.org/content/canres/78/16/4512/F1.large.jpg <i></i>.
The significant correlation of p185 with several tumor-associated proteases supports the hypothesis that c-erbB-2 is a promoter of invasion and metastasis.
From 9/37 patients with p185 overexpression of the primary tumor in immunohistochemical analysis 3/9 patients with metastatic disease had elevated serum levels higher than 30 kU/l.
In metastatic breast tumors p185 HER2 was demonstrated homogeneously among multiple autologous lesions and almost invariably (80%) the expression of p185 in the primary lesion correlated with that of the deriving metastases.