Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | group | BEFREE | Therefore, the pharmacological inhibition of Cdk5/p25 alleviates tau-associated neurological disorders. | 31073393 | 2019 | ||||
|
0.080 | Biomarker | group | BEFREE | Dysfunction of CDK5 has been associated with a number of neurological disorders. | 30618612 | 2018 | ||||
|
0.080 | Biomarker | group | BEFREE | Cyclin-dependent kinase 5 (Cdk5) acts as an essential modulator for neural development and neurological disorders. | 29031852 | 2018 | ||||
|
0.080 | Biomarker | group | BEFREE | p35 is an activating co-factor of Cyclin-dependent kinase 5 (Cdk5), a protein whose dysfunction has been implicated in a wide-range of neurological disorders including cognitive impairment and disease. | 29867369 | 2018 | ||||
|
0.080 | GeneticVariation | group | BEFREE | In addition, fast decompression affected several proteins taking parts in these two main mechanisms of synaptic strength, especially alteration in CDK5/calcineurin are associated with a broad range of neurological disorders. | 28977037 | 2017 | ||||
|
0.080 | AlteredExpression | group | BEFREE | However, Cdk5 activity becomes deregulated in several neurological disorders, such as Alzheimer's disease, Parkinson's disease and Huntington's disease, which leads to neurotoxicity. | 24879856 | 2014 | ||||
|
0.080 | Biomarker | group | BEFREE | Dysfunction of Cdk5 has been implicated in a number of neurological disorders and neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Niemann-Pick type C disease, and ischemia. | 21740229 | 2011 | ||||
|
0.080 | AlteredExpression | group | BEFREE | The calpain-mediated cleavage of p35 to p25 and the resulting aberrant activity and neurotoxicity of Cdk5 have been implicated in neurological disorders, such as Alzheimer's disease. | 21338355 | 2011 |