Gene: CLOCK ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 Biomarker disease BEFREE Disruption of clock genes results in dyslipidemia, insulin resistance and obesity, all predisposing to atherosclerosis. 17765229 2008
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 GeneticVariation disease BEFREE Present findings show for the first time that the 3111T/C SNP of the CLOCK gene is not associated to human obesity and/or BED, but it seems to predispose obese individuals to a higher BMI. 18314271 2008
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 GeneticVariation disease BEFREE These findings suggest that the Clock gene CGC haplotype may be protective for the development of obesity and support the hypothesis that genetic variation in the Clock gene may play a role in the development of the metabolic syndrome, type 2 diabetes and cardiovascular disease. 18071340 2008
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 Biomarker disease BEFREE A series of our recent studies revealed that circadian clock proteins are important for hypofibrinolysis induced by metabolic disorders such as obesity and diabetes. 19387897 2009
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 GeneticVariation disease BEFREE Thus, recent research has implicated mutations and polymorphisms of circadian clock genes in diabetes and obesity, cardiovascular disease, and cancer. 20307570 2010
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 GeneticVariation disease BEFREE Animal models have shown that mice with Clock gene disruption are prone to developing obesity and MetS. 20567242 2010
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 AlteredExpression disease BEFREE These results suggest mRNA expression of clock genes is associated with obesity, glucose tolerance, and ethanol consumption even in healthy people. 20205566 2010
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 GeneticVariation disease BEFREE We have replicated previous studies showing a relationship between CLOCK gene polymorphisms and obesity. 20065968 2010
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 GeneticVariation disease BEFREE Previous studies have found associations between single nucleotide polymorphisms in clock genes or downstream hormone receptors such as the leptin receptor (LEPR) or glucocorticoid receptor (NR3C1) and obesity in the healthy population, but this association remains to be examined in patients with schizophrenia treated with antipsychotics. 21050724 2011
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 GeneticVariation disease BEFREE The aim of this research was to investigate the influence of obesity and metabolic syndrome (MetS) features in clock gene methylation and the involvement of these epigenetic modifications in the outcomes. 23003921 2012
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 GeneticVariation disease BEFREE Our results showed that women carrying the C allele of CLOCK gene had a marginally significant lower risk of overweight/obesity compared with noncarrier-TT-subjects (odds ratio [OR]: .61, 95% confidence interval [CI]: .36-1.04; p = .069). 23131019 2012
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 Biomarker disease BEFREE Dysfunction of the circadian clock genes is involved in the development of obesity and type 2 diabetes (T2D). 23323702 2013
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 GeneticVariation disease BEFREE Overall, the most studied area has been the association of CLOCK gene with obesity; close to eight common variants have been associated with obesity. 26553137 2015
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 Biomarker disease BEFREE Single nucleotide polymorphisms (SNPs) of the circadian locomotor output cycles kaput (CLOCK) gene have been associated with cardiometabolic conditions such as obesity and dyslipidemia. 26346429 2015
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 GeneticVariation disease BEFREE To evaluate the association between 3111T/C polymorphism of the CLOCK gene and the presence of obesity and sleep duration in children aged 6-13 years. 24818524 2015
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 GeneticVariation disease BEFREE Variant of the CLOCK gene and related haplotypes are associated with the prevalence of T2D in the Japanese population, in which obesity is less common, and the association between CLOCK gene variant at rs1801260 and the prevalence of diabetes is enhanced in normal-weight subjects. 26374515 2016
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 GeneticVariation disease BEFREE However, little is known about the relationship between circadian preferences and genetic background in CLOCK genes with obesity and weight loss among severely obese patients after bariatric surgery. 27339606 2016
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 GeneticVariation disease BEFREE Several SNP in clock genes are related to obesity and weight loss. 27339810 2016
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 Biomarker disease BEFREE Consequently, disruption of clock genes results in dyslipidemia, insulin resistance and obesity. 28585194 2017
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 GeneticVariation disease BEFREE These findings suggest that a change in photoperiod can partly disrupt the circadian rhythmcity of clock genes, impair lipid metabolism, and promote obesity. 28708429 2017
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 GeneticVariation disease BEFREE Circadian CLOCK gene polymorphisms in relation to sleep patterns and obesity in African Americans: findings from the Jackson heart study. 28645331 2017
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 AlteredExpression disease BEFREE In particular, abdominal obesity, which contributes to the pathogenesis of metabolic disease, is associated with disrupted clock gene expression. 28650669 2017
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 GeneticVariation disease BEFREE The epigenetic changes of clock genes driving metabolic disease and obesity development have also been included in this review. 27846625 2017
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 Biomarker disease BEFREE Obesity-induced changes in hepatic and placental clock gene networks in rat pregnancy. 29186286 2018
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 GeneticVariation disease BEFREE Disruptions in clock genes have been associated with obesity and related comorbidities. 29580070 2018