| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.600 | Biomarker | disease | BEFREE | This study suggests that there are sex differences in 11β-HSD1 regulation and in its associations with markers of obesity and IR. | 23701286 | 2013 | ||||
|
0.600 | Biomarker | disease | BEFREE | Thus, 11β-HSD1 is a promising target for the treatment and prevention of type 2 diabetes mellitus with obesity. | 29078846 | 2017 | ||||
|
0.600 | AlteredExpression | disease | BEFREE | To further characterize the tissue-specific cortisol regeneration in obesity, we have investigated the mRNA expression of genes related to local cortisol production, i.e., 11β-HSD1, hexose-6-phosphate dehydrogenase (H6PDH) and cortisol action, glucocorticoid receptor (GR) and a cortisol target gene, phosphoenolpyruvate carboxykinase (PEPCK) in the liver, and visceral (VAT) and subcutaneous (SAT) adipose tissues from morbidly obese patients with and without metabolic syndrome (MS). | 21964795 | 2012 | ||||
|
0.600 | GeneticVariation | disease | BEFREE | To investigate the relationship between 11β-hydroxysteroid dehydrogenase (HSD11B) gene type 1 and 2 and obesity in Chinese children. | 24729284 | 2014 | ||||
|
0.600 | GeneticVariation | disease | BEFREE | We confirmed that adipocyte 11beta-HSD1 mRNA concentrations were associated with adiposity, and showed that genetic variations in the HSD11B1 gene were associated with Type 2 diabetes mellitus, plasma insulin concentrations and insulin action, independent of obesity. | 15156315 | 2004 | ||||
|
0.600 | AlteredExpression | disease | BEFREE | We hypothesized that obesity and elevated intracranial pressure may be linked through increased 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity. | 20826586 | 2010 | ||||
|
0.600 | AlteredExpression | disease | BEFREE | We hypothesized that 11β-HSD1 activity is dysregulated in obesity and alters following bariatric surgery induced weight loss in different tissues. | 25603461 | 2015 | ||||
|
0.600 | AlteredExpression | disease | BEFREE | We suggest that the disruption of Ifi202b in B6 is responsible for the effects of the obesity QTL Nob3, and that Ifi202b modulates fat accumulation through expression of adipogenic genes such as 11β-Hsd1. | 22692684 | 2012 |