Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.380 | Biomarker | disease | BEFREE | Zollinger-Ellison syndrome (ZES) is a rare condition characterized by hypersecretion of gastrin by gastrinoma tumors leading to severe peptic ulcer disease with potential development of gastric carcinoid tumors. | 31818296 | 2019 | ||||
|
0.380 | Biomarker | disease | BEFREE | MD is typically accompanied by ectopic gastric tissue, and could therefore be affected by gastrin and acid secretion in a similar manner to PU. | 28673591 | 2017 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | Only ~10% of chronically infected patients, mainly the young, manifest an antral predominant gastritis with increased acid secretion due to a decrease in somatostatin and increase in gastrin secretion; these patients are predisposed to develop peptic ulcer disease. | 28124156 | 2017 | ||||
|
0.380 | AlteredExpression | disease | BEFREE | Two patients experienced adverse events after proton pump inhibitor therapy was discontinued to re-measure serum gastrin level during the evaluation of severe peptic ulcer disease. | 28011308 | 2017 | ||||
|
0.380 | Biomarker | disease | BEFREE | Toll-Like Receptor 4 Wild Type Homozygozity of Polymorphisms +896 and +1196 Is Associated with High Gastrin Serum Levels and Peptic Ulcer Risk. | 26161647 | 2015 | ||||
|
0.380 | AlteredExpression | disease | BEFREE | ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal reflux disease and occasional diarrhea. | 17006979 | 2006 | ||||
|
0.380 | Biomarker | disease | CTD_human | Gastrin is also implicated in the genesis of peptic ulcer disease both in conjunction with H. pylori infections and with gastrin-producing tumors. | 10700044 | 2000 | ||||
|
0.380 | AlteredExpression | disease | BEFREE | Gastric juice pH and serum gastrin levels were measured in patients with peptic ulcer disease. | 10616759 | 1999 | ||||
|
0.380 | Biomarker | disease | BEFREE | The usual therapeutic approach has been to perform parathyroidectomy first before surgery for ulcer disease in an effort to decrease serum calcium concentration and presumably remove one of the stimuli for both gastrin and gastric acid secretion. | 3798319 | 1987 |