Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.370 | AlteredExpression | disease | BEFREE | It is evident, therefore, that high levels of IGF-II in combination with overexpression of the IGF-I-receptor can provide a significant growth advantage for adrenocortical carcinoma cells and thus contribute to the highly malignant phenotype of this rare type of cancer. | 15241731 | 2004 | ||||
|
0.370 | Biomarker | disease | BEFREE | The molecular characterization of adrenocortical carcinoma has identified dysregulation of the Gap 2/mitosis transition and the insulin-like growth factor 1 receptor signaling cascade as two major pathways for therapeutic development. | 21045685 | 2011 | ||||
|
0.370 | AlteredExpression | disease | BEFREE | IGF1R expression levels were significantly higher in pediatric adrenocortical carcinomas, suggesting that IGF1R expression represents a potential prognostic marker in this group of patients. | 22019903 | 2012 | ||||
|
0.370 | Biomarker | disease | CTD_human | Liposomal doxorubicin-based treatment in a preclinical model of adrenocortical carcinoma. | 22407999 | 2012 | ||||
|
0.370 | Biomarker | disease | BEFREE | IGF1R amplification was detected in an adrenocortical carcinoma that was diagnosed in a 46-year-old woman with Cushing's syndrome and virilization. | 25110710 | 2014 | ||||
|
0.370 | Biomarker | disease | BEFREE | We have previously demonstrated that estrogen receptor (ER) alpha (ESR1) increases proliferation of adrenocortical carcinoma (ACC) through both an estrogen-dependent and -independent (induced by IGF-II/IGF1R pathways) manner. | 26131713 | 2015 | ||||
|
0.370 | Biomarker | disease | BEFREE | The pathogenesis of the adrenocortical cancer (ACC) involves integration of molecular signals and the interplay of different downstream pathways (i.e.IGFII/IGF1R, β-catenin, Wnt, ESR1). | 26312764 | 2015 | ||||
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0.370 | Biomarker | disease | BEFREE | After 24h, the treatment also decreased the expression of genes related to the steroid biosynthetic process, the protein levels of the steroidogenic acute regulatory protein (STAR), and androgen secretion in cell medium, supporting the role of IGF1R in steroidogenesis of adrenocortical carcinoma cells. | 27185872 | 2016 |