To establish a model of E.faecalis LTA infection of osteoclasts, the relationship between BTK and bone destruction during refractory periapical periodontitis was analyzed.
Studies have shown that the Bruton tyrosine kinase- (Btk-) phospholipase C<i>γ</i>2 (PLC<i>γ</i>2) signaling pathway plays an important role in bone absorption, but it is unknown whether it plays a role in apical periodontitis bone destruction.