| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | GeneticVariation | disease | BEFREE | The current study sought to investigate the relationship between variations in ADRB2 and childhood asthma. | 26633084 | 2016 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | We performed a case-control study to investigate the association of 4 SNPs in the ADRB2 gene with risk of asthma in children, and then conducted a meta-analysis by combining the previous studies. | 26994621 | 2016 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | Four ADRB2 single nucleotide polymorphisms (rs1042711, rs1042713, rs1042714 and rs1800888) were genotyped in 953 children from the prospective birth cohort 'Environment and Childhood Asthma' study and analysed for association with flow-volume parameters at birth (tidal breathing) and at 10 years of age (maximally forced), stratified by environmental exposures. | 23463918 | 2013 | ||||
|
0.070 | Biomarker | disease | BEFREE | These findings support the potential use of ADRB2 5'-UTR methylation as a biomarker of both asthma severity and risk for NO (2) -associated asthma exacerbations in children, and present the first evidence of an epigenetic link between an important environmental exposure and childhood asthma severity. | 22862293 | 2012 | ||||
|
0.070 | Biomarker | disease | BEFREE | We studied whether variations in single nucleotide polymorphisms (SNPs) in the TNF, glutathione S transferase P1 (GSTP1) and beta2-adrenoreceptor (ADRB2) genes modify the effect of early maternal smoking on the development of childhood asthma, wheeze and allergic sensitization. | 20210814 | 2010 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | Genes located on chromosome 5q (ADRB2, IL13 and IL4) and the recently identified ORMDL3, on chromosome 17, seem to be determinants of childhood asthma. | 18690379 | 2008 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | ADRB2 polymorphisms might predict a small component of the long-term prognosis in childhood asthma, but are not important determinants of asthma incidence or prevalence in the British population. | 16935688 | 2006 |