| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | This study shows that the current PPA classification system helps to predict underlying pathology across different cohorts and clinical settings, and suggests that age and ApoE genotype should be considered when interpreting amyloid-β biomarkers in PPA patients.Ann Neurol 2018;84:737-748. | 30255971 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | APOE ε4 increases the risk of β-amyloid deposition in PPA and progressive speech apraxia but does not influence regional β-amyloid distribution or severity. | 24985533 | 2014 | ||||
|
0.080 | Biomarker | disease | BEFREE | Genetic distributions and allele frequencies of FOXP2 and PRNP polymorphisms did not differ between groups while APOE ε4 was more represented in PPA as compared to controls. | 22129783 | 2012 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Inside this region of 16.3 kb, LD (r2 = 0.14) between TOMM40 (rs157590) and APOE (rs429358) was observed in PPA, but not in bvFTD and in controls. | 22710912 | 2012 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Significant associations with PPA were also observed for genotypes APOE ε3/ε4 (OR, 22.5; 95% CI, 1.2-229.4) and ε4/ε4 (OR, 7.5; 95% CI, 2.6-21.6). | 21555637 | 2011 | ||||
|
0.080 | Biomarker | disease | BEFREE | Apolipoprotein E genotyping was obtained from 149 patients with a clinical diagnosis of PPA, 330 cognitively healthy individuals (NC), and 179 patients with a clinical diagnosis of probable Alzheimer's disease (PrAD). | 21346518 | 2011 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | The role of the Apolipoprotein E (APOE) alleles in syndromes associated with focal cerebral atrophy (fronto-temporal dementia, primary progressive aphasia, corticobasal degeneration) is still controversial. | 11311499 | 2001 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Apolipoprotein E genotypes in primary progressive aphasia. | 9222169 | 1997 |