We propose to create a calcification next generation sequencing (NGS) panel with <i>NT5E, GGCX, ENPP1</i>, and <i>ABCC6</i> genes to improve the molecular diagnosis of vascular calcification.
Vitamin K-dependent carboxylation, an essential posttranslational modification catalyzed by gamma-glutamyl carboxylase, is required for the biological functions of proteins that control blood coagulation, vascular calcification, bone metabolism, and other important physiological processes.