| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | Biomarker | group | BEFREE | Deregulated STAT5 activation has been found in the development of many hematopoietic tumors, including chronic and acute leukemias, polycythemia vera, and lymphoma. | 30783189 | 2019 | ||||
|
0.090 | GeneticVariation | group | BEFREE | Our findings might help explain the high frequency of STAT5B mutations in hematopoietic tumors. | 30679796 | 2019 | ||||
|
0.090 | AlteredExpression | group | BEFREE | In this review, we discuss the functions and the roles of unphosphorylated STAT3/5 in the context of chromatin remodeling, as well as the impact of STAT5 oligomerization on differential gene expression in hematopoietic neoplasms. | 31817042 | 2019 | ||||
|
0.090 | GeneticVariation | group | BEFREE | STAT5B is often mutated in hematopoietic malignancies. | 29200404 | 2018 | ||||
|
0.090 | Biomarker | group | BEFREE | Here we review past and current research on STAT genes in hematopoietic and solid cancers with emphasis on STAT3 and STAT5B and their roles in the pathogenesis of hematopoietic malignancies, particularly T-LGL leukemia and CLPD-NK. | 29417693 | 2018 | ||||
|
0.090 | AlteredExpression | group | BEFREE | STAT5 transcription factors are frequently activated in hematopoietic neoplasms and are targets of various tyrosine kinase oncogenes. | 27566554 | 2017 | ||||
|
0.090 | AlteredExpression | group | BEFREE | Furthermore, constitutive Ser-193 phosphorylation is associated with Stat5b proto-oncogenic activity and therefore may serve as a novel therapeutic target for treating hematopoietic malignancies. | 22442148 | 2012 | ||||
|
0.090 | Biomarker | group | BEFREE | The role of Stat5 in breast cancer has not been established, although Stat5 is critical for some hematopoietic malignancies. | 12459712 | 2002 | ||||
|
0.090 | Biomarker | group | BEFREE | Stat5 activation has been primarily demonstrated in hematopoietic malignancies. | 11973644 | 2002 |