| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | Biomarker | group | BEFREE | Finally, we review how aberrant forms of RUNX1 deregulate blood cell development and cause hematopoietic malignancies. | 28299651 | 2017 | ||||
|
0.090 | AlteredExpression | group | BEFREE | Disruption of RUNX1 activity has been implicated in the development of hematopoietic neoplasms. | 28536267 | 2017 | ||||
|
0.090 | GeneticVariation | group | BEFREE | Finally, we describe how alterations of RUNX1, or the enzymes that catalyze its post-translational modifications, contribute to hematopoietic malignancies. | 28299649 | 2017 | ||||
|
0.090 | AlteredExpression | group | BEFREE | RUNX1/AML1, which is a Runt family transcription factor critical for normal hematopoiesis, is frequently mutated or translocated in a broad spectrum of hematopoietic malignancies. | 25879624 | 2015 | ||||
|
0.090 | AlteredExpression | group | BEFREE | Disruption of RUNX1 activity has been implicated in the development of hematopoietic neoplasms. | 25263451 | 2015 | ||||
|
0.090 | PosttranslationalModification | group | BEFREE | An intragenic long noncoding RNA interacts epigenetically with the RUNX1 promoter and enhancer chromatin DNA in hematopoietic malignancies. | 24752773 | 2014 | ||||
|
0.090 | Biomarker | group | BEFREE | The disruption of RUNX1 function is one of the main mechanisms of disease observed in hematopoietic malignancies and the description of novel genetic events that lead to a RUNX1 loss of function has been accelerated with the development of genomic technologies. | 22102704 | 2012 | ||||
|
0.090 | Biomarker | group | BEFREE | RUNX1 was originally identified as a gene fusion in acute myeloid leukemia (AML) and thus has garnered heavy attention as a tumor suppressor in hematopoietic malignancies. | 22024923 | 2011 | ||||
|
0.090 | GeneticVariation | group | BEFREE | The TEL and AML1 genes are common targets of chromosomal translocations in hematopoietic malignancies. | 10049061 | 1999 |