| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | Biomarker | disease | BEFREE | In this study group, results documented that local expansion of IL-17-producing cells in the digestive tract correlate with moderate and severe clinical symptoms of cGvHD, in contrast to the skin, where IL-17<sup>+</sup> cells are rather scarcely present (p = 0.0301) and the course of cGvHD is slowly progressing with final organ deterioration. | 31177288 | 2019 | ||||
|
0.070 | Biomarker | disease | BEFREE | Increased production of IL-17 and more infiltration of T cells and macrophages in cGVHD mice were markedly reduced after hCB-MDSCs treatment. | 30006304 | 2018 | ||||
|
0.070 | Biomarker | disease | BEFREE | Knockdown of IL-17 in IL-1Ra-KO donor mice significantly attenuated the IL-1-induced acceleration of cGVHD severity. | 30042768 | 2018 | ||||
|
0.070 | Biomarker | disease | BEFREE | Of note, MSCs-exo exhibited potent immunomodulatory effects via the inhibition of IL-17-expressing pathogenic T cells and induction of IL-10-expressing regulatory cells during cGVHD. | 30526632 | 2018 | ||||
|
0.070 | Biomarker | disease | BEFREE | Overall, our results provide new mechanistic insights that activation of C5a-C5aR signaling was required for IL-17A-induced immune responses in cGVHD and define novel molecular targets for developing effective therapeutics for cGVHD. | 30093951 | 2018 | ||||
|
0.070 | Biomarker | disease | BEFREE | Substantial preclinical and clinical research into chronic graft-versus-host disease (cGVHD) has come to fruition in the last five years, generating a clear understanding of a complex cytokine-driven cellular network. cGVHD is mediated by naive T cells differentiating within IL-17-secreting T cell and follicular Th cell paradigms to generate IL-21 and IL-17A, which drive pathogenic germinal center (GC) B cell reactions and monocyte-macrophage differentiation, respectively. cGVHD pathogenesis includes thymic damage, impaired antigen presentation, and a failure in IL-2-dependent Treg homeostasis. | 28665299 | 2017 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | No association was observed between IL-17A levels and cGVHD. | 25136146 | 2014 |