| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | phenotype | BEFREE | The double tumor suppressors ING4/PTEN could inhibit the growth of U87 glioma cells with a synergistic antitumor effect, and the RGD modification also acted as an anti-oncogene to inhibit U87 cell invasion and tumor angiogenesis. | 28407709 | 2020 | ||||
|
0.080 | AlteredExpression | phenotype | BEFREE | In summary, the results of the present study demonstrated that nimesulide could induce apoptosis and inhibit growth of PANC-1 cells by enhancing the expression of PTEN, which indicates the potential of nimesulide to prevent tumor angiogenesis. | 29896263 | 2018 | ||||
|
0.080 | Biomarker | phenotype | BEFREE | The synergistic tumor suppression elicited by AdVING4/PTEN was closely associated with the synergistic induction of apoptosis possibly via enhancement of endogenous p53 responses through cooperatively facilitating p53's stability and acetylation, and the synergistic inhibition of tumor angiogenesis probably via overlapping reduction of VEGF through cooperatively downregulating hypoxia inducible factor-1α's level and transcription activity. | 26564429 | 2016 | ||||
|
0.080 | AlteredExpression | phenotype | BEFREE | The enhanced antitumor activity generated by Ad.RGD-ING4-PTEN was closely associated with activation of the intrinsic and extrinsic apoptotic pathways and additive inhibition of tumor angiogenesis both in vitro and in vivo. | 25571952 | 2015 | ||||
|
0.080 | Biomarker | phenotype | BEFREE | Therefore, we demonstrate that miR-21 induces tumor angiogenesis through targeting PTEN, leading to activate AKT and ERK1/2 signaling pathways, and thereby enhancing HIF-1α and VEGF expression; HIF-1α is a key downstream target of miR-21 in regulating tumor angiogenesis. | 21544242 | 2011 | ||||
|
0.080 | Biomarker | phenotype | BEFREE | These results suggest that inhibition of PI3K signaling pathway by PTEN inhibits tumor angiogenesis and tumor growth. | 17826033 | 2007 | ||||
|
0.080 | AlteredExpression | phenotype | BEFREE | The purpose of this study was to evaluate PTEN expression in the successive steps of progression in cervical neoplasia and to determine its correlation with tumor angiogenesis and clinicopathologic features in squamous cell carcinoma of the uterine cervix. | 16482604 | 2006 | ||||
|
0.080 | Biomarker | phenotype | BEFREE | The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. | 16107612 | 2005 |