Source: CLINVAR ×
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923
CREBBP Q92793 CREB binding protein 1.00 0.428 0.808
MED12 Q93074 mediator complex subunit 12 Transcription factor 1.00 0.476 0.769
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885
PTPN11 Q06124 protein tyrosine phosphatase non-receptor type 11 1.00 0.385 0.923
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846
FGFR1 P11362 fibroblast growth factor receptor 1 Kinase 1.00 0.362 0.885
FBXW7 Q969H0 F-box and WD repeat domain containing 7 Enzyme modulator 1.00 0.465 0.808
SMAD4 Q13485 SMAD family member 4 Transcription factor 1.00 0.401 0.808
FGFR2 P21802 fibroblast growth factor receptor 2 Kinase 1.00 0.380 0.808
CNOT9 Q92600 CCR4-NOT transcription complex subunit 9 0.99 0.769 0.192
PPP2R1A P30153 protein phosphatase 2 scaffold subunit Aalpha Enzyme 0.98 0.588 0.577
KIT P10721 KIT proto-oncogene, receptor tyrosine kinase Kinase 0.98 0.366 0.808
MAP2K2 P36507 mitogen-activated protein kinase kinase 2 Kinase 0.97 0.534 0.731
MAP2K1 Q02750 mitogen-activated protein kinase kinase 1 Kinase 0.90 0.439 0.846
RAF1 P04049 Raf-1 proto-oncogene, serine/threonine kinase Kinase 0.85 0.418 0.885
GNAS O95467 P63092 P84996 Q5JWF2 GNAS complex locus Enzyme modulator 0.68 0.420 0.885
RHOA P61586 ras homolog family member A Enzyme modulator 0.60 0.502 0.808
B2M P61769 beta-2-microglobulin Immune response 0.56 0.447 0.846
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885
ACVR1 Q04771 activin A receptor type 1 Kinase 0.33 0.535 0.731
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923