Disease: Breast Cancer, Familial
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923
MDM2 Q00987 MDM2 proto-oncogene Nucleic acid binding 1.00 0.362 0.846
MGMT P16455 O-6-methylguanine-DNA methyltransferase 1.2E-07 0.412 0.885
MLH1 P40692 mutL homolog 1 Nucleic acid binding 3.4E-05 0.399 0.808
MSH2 P43246 mutS homolog 2 Nucleic acid binding 0.90 0.406 0.808
MSH3 P20585 mutS homolog 3 Nucleic acid binding 7.4E-31 0.474 0.769
MSH6 P52701 mutS homolog 6 Nucleic acid binding 3.7E-05 0.462 0.731
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885
MUTYH Q9UIF7 mutY DNA glycosylase Enzyme 1.3E-18 0.521 0.769
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923
NBN O60934 nibrin Nucleic acid binding 2.2E-16 0.467 0.808
NLRP2 Q9NX02 NLR family pyrin domain containing 2 1.4E-38 0.515 0.731
PALB2 Q86YC2 partner and localizer of BRCA2 3.0E-19 0.485 0.769
PARP1 P09874 poly(ADP-ribose) polymerase 1 3.3E-04 0.389 0.923
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923
PMS2 P54278 PMS1 homolog 2, mismatch repair system component Nucleic acid binding 4.5E-27 0.484 0.808
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923
PTPRG P23470 protein tyrosine phosphatase receptor type G Enzyme 5.1E-06 0.619 0.731
RAD51C O43502 RAD51 paralog C 6.2E-14 0.533 0.692
RASSF1 Q9NS23 Ras association domain family member 1 Enzyme modulator 4.9E-06 0.420 0.808
RINT1 Q6NUQ1 RAD50 interactor 1 5.3E-13 0.743 0.231
STK11 Q15831 serine/threonine kinase 11 Kinase 0.99 0.435 0.808
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962