Disease: Hereditary Nonpolyposis Colorectal Neoplasms
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885
BARD1 Q99728 BRCA1 associated RING domain 1 1.4E-24 0.597 0.538
BAX Q07812 BCL2 associated X, apoptosis regulator Signaling 0.32 0.417 0.885
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846
CD44 P16070 CD44 molecule (Indian blood group) 2.4E-07 0.363 0.962
CDH1 P12830 cadherin 1 0.15 0.401 0.808
CDKN1B P46527 cyclin dependent kinase inhibitor 1B 0.62 0.409 0.769
CHEK2 O96017 checkpoint kinase 2 Kinase 1.2E-24 0.460 0.808
COMT P21964 catechol-O-methyltransferase Enzyme 1.1E-06 0.400 0.923
CTNNA1 P35221 catenin alpha 1 Cellular structure 0.97 0.584 0.538
CYP17A1 P05093 cytochrome P450 family 17 subfamily A member 1 2.6E-04 0.462 0.769
CYP1A1 P04798 cytochrome P450 family 1 subfamily A member 1 Enzyme 1.1E-17 0.436 0.846
EPCAM P16422 epithelial cell adhesion molecule 1.3E-07 0.451 0.885
EPHX1 P07099 epoxide hydrolase 1 3.2E-09 0.500 0.846
EXO1 Q9UQ84 exonuclease 1 Enzyme 8.1E-13 0.578 0.692
FAN1 Q9Y2M0 FANCD2 and FANCI associated nuclease 1 1.7E-25 0.610 0.577
FBXO11 Q86XK2 F-box protein 11 Enzyme 1.00 0.604 0.692
MLH1 P40692 mutL homolog 1 Nucleic acid binding 3.4E-05 0.399 0.808
MLH3 Q9UHC1 mutL homolog 3 Nucleic acid binding 4.9E-08 0.582 0.538
MSH2 P43246 mutS homolog 2 Nucleic acid binding 0.90 0.406 0.808
MSH3 P20585 mutS homolog 3 Nucleic acid binding 7.4E-31 0.474 0.769
MSH6 P52701 mutS homolog 6 Nucleic acid binding 3.7E-05 0.462 0.731
NFKBIZ Q9BYH8 NFKB inhibitor zeta 1.00 0.674 0.577
PALB2 Q86YC2 partner and localizer of BRCA2 3.0E-19 0.485 0.769