Disease: Hereditary non-polyposis colorectal cancer syndrome
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885
BARD1 Q99728 BRCA1 associated RING domain 1 1.4E-24 0.597 0.538
CDH1 P12830 cadherin 1 0.15 0.401 0.808
CDKN1B P46527 cyclin dependent kinase inhibitor 1B 0.62 0.409 0.769
CHEK2 O96017 checkpoint kinase 2 Kinase 1.2E-24 0.460 0.808
CTNNA1 P35221 catenin alpha 1 Cellular structure 0.97 0.584 0.538
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885
EPCAM P16422 epithelial cell adhesion molecule 1.3E-07 0.451 0.885
EPHX1 P07099 epoxide hydrolase 1 3.2E-09 0.500 0.846
EXO1 Q9UQ84 exonuclease 1 Enzyme 8.1E-13 0.578 0.692
FAN1 Q9Y2M0 FANCD2 and FANCI associated nuclease 1 1.7E-25 0.610 0.577
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923
MIR223 microRNA 223 0.433 0.808
MIR31 microRNA 31 0.471 0.769
MLH1 P40692 mutL homolog 1 Nucleic acid binding 3.4E-05 0.399 0.808
MLH3 Q9UHC1 mutL homolog 3 Nucleic acid binding 4.9E-08 0.582 0.538
MRC1 P22897 mannose receptor C-type 1 0.94 0.413 0.846
MSH2 P43246 mutS homolog 2 Nucleic acid binding 0.90 0.406 0.808
MSH3 P20585 mutS homolog 3 Nucleic acid binding 7.4E-31 0.474 0.769
MSH6 P52701 mutS homolog 6 Nucleic acid binding 3.7E-05 0.462 0.731
NFKBIZ Q9BYH8 NFKB inhibitor zeta 1.00 0.674 0.577
PALB2 Q86YC2 partner and localizer of BRCA2 3.0E-19 0.485 0.769
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923
PMS1 P54277 PMS1 homolog 1, mismatch repair system component Nucleic acid binding 1.3E-17 0.569 0.654
PMS2 P54278 PMS1 homolog 2, mismatch repair system component Nucleic acid binding 4.5E-27 0.484 0.808