Disease: Hereditary Nonpolyposis Colorectal Cancer
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923
BRCA2 P51587 BRCA2 DNA repair associated Nucleic acid binding 2.4E-25 0.379 0.846
BRIP1 Q9BX63 BRCA1 interacting protein C-terminal helicase 1 Enzyme 6.2E-17 0.507 0.731
CDH1 P12830 cadherin 1 0.15 0.401 0.808
CDKN1B P46527 cyclin dependent kinase inhibitor 1B 0.62 0.409 0.769
CHEK2 O96017 checkpoint kinase 2 Kinase 1.2E-24 0.460 0.808
CYP17A1 P05093 cytochrome P450 family 17 subfamily A member 1 2.6E-04 0.462 0.769
CYP1A1 P04798 cytochrome P450 family 1 subfamily A member 1 Enzyme 1.1E-17 0.436 0.846
CYP1B1 Q16678 cytochrome P450 family 1 subfamily B member 1 Enzyme 2.2E-05 0.457 0.769
DNMT3B Q9UBC3 DNA methyltransferase 3 beta 0.20 0.453 0.846
GSTK1 Q9Y2Q3 glutathione S-transferase kappa 1 1.9E-06 0.412 0.885
GSTM1 P09488 glutathione S-transferase mu 1 2.1E-03 0.380 0.923
GSTP1 P09211 glutathione S-transferase pi 1 1.4E-02 0.383 0.923
GSTT1 P30711 glutathione S-transferase theta 1 1.5E-04 0.393 0.923
KLF6 Q99612 Kruppel like factor 6 Nucleic acid binding 0.98 0.501 0.846
MLH1 P40692 mutL homolog 1 Nucleic acid binding 3.4E-05 0.399 0.808
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923
NBN O60934 nibrin Nucleic acid binding 2.2E-16 0.467 0.808
PALB2 Q86YC2 partner and localizer of BRCA2 3.0E-19 0.485 0.769
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923
RNASEL Q05823 ribonuclease L Kinase 2.0E-10 0.579 0.692
RNF43 Q68DV7 ring finger protein 43 0.73 0.584 0.577
SLCO6A1 Q86UG4 solute carrier organic anion transporter family member 6A1 Transporter 2.9E-11 0.412 0.885
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962