|
rs1344800847
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In AD patients carrying the H allele (<i>Hin</i>dIII polymorphism) or the Q allele (Q981H polymorphism), CR1/E was significantly lower when compared with controls carrying the same alleles (<i>p</i> < 0.01), contrary to sCR1, which was significantly higher (<i>p</i> < 0.001).
|
30044434 |
2018 |
|
rs3738467
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In AD patients carrying the H allele (<i>Hin</i>dIII polymorphism) or the Q allele (Q981H polymorphism), CR1/E was significantly lower when compared with controls carrying the same alleles (<i>p</i> < 0.01), contrary to sCR1, which was significantly higher (<i>p</i> < 0.001).
|
30044434 |
2018 |
|
rs4844609
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Ser1610Thr variant was not associated with AD</span>, memory impairment, total tau, amyloid β(1-42) or tau phosphorylated at threonine 181 levels.
|
23582656 |
2013 |
|
rs2093760
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
|
30617256 |
2019 |
|
rs12036785
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
GWAS on family history of Alzheimer's disease.
|
29777097 |
2018 |
|
rs679515
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
A novel Alzheimer disease locus located near the gene encoding tau protein.
|
25778476 |
2016 |
|
rs1408077
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
|
21460841 |
2011 |
|
rs1408078
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
|
21460841 |
2011 |
|
rs2296160
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
|
21460841 |
2011 |
|
rs4844610
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Individuals with F/S genotype had a 1.8 times increased risk for AD compared with F/F genotype (p-adjusted = 0.003), while rs4844610 was only marginally significant (p-adjusted = 0.024).
|
22819390 |
2012 |
|
rs4844610
|
|
|
0.710 |
GeneticVariation |
GWASDB |
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
|
21460841 |
2011 |
|
rs6701713
|
|
|
0.810 |
GeneticVariation |
GWASCAT |
GWAS on family history of Alzheimer's disease.
|
29777097 |
2018 |
|
rs6701713
|
|
|
0.810 |
GeneticVariation |
BEFREE |
In this case-control study, we aimed to investigate whether single nucleotide polymorphisms in MTHFR (rs1801133), PICALM (3851719), CLU (rs11136000), and CR1 (rs6701713) are associated with AD.
|
25359311 |
2015 |
|
rs6701713
|
|
A |
0.810 |
GeneticVariation |
GWASCAT |
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
|
21460841 |
2011 |
|
rs6701713
|
|
A |
0.810 |
GeneticVariation |
GWASDB |
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
|
21460841 |
2011 |
|
rs3818361
|
|
|
0.880 |
GeneticVariation |
BEFREE |
The aim of this study was to examine whether the variants of some candidate genes involved in the development of AD, namely BIN1 (rs744373), CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179), are related to several disorders of glucose metabolism-gestational diabetes (GDM), T2DM and impaired glucose tolerance (IGT).
|
28316001 |
2017 |
|
rs3818361
|
|
|
0.880 |
GeneticVariation |
BEFREE |
In summary, this is the first study to show significan</span></span>t association between rs3818361 polymorphism and AD in Chinese population by a meta-analysis method.
|
26189835 |
2016 |
|
rs3818361
|
|
|
0.880 |
GeneticVariation |
BEFREE |
Our prevalent case study comparing prevalent AD cases (n = 428) with participants with no cognitive impairment (n = 524) revealed a significant association of rs6656401 and rs3818361 (CR1), rs2075650 (TOMM40), rs7561528 (BIN1), and rs3865444 (CD33) with late-onset AD that were robust to adjustment with age and apolipoprotein E ε4 genotype.
|
24176626 |
2014 |
|
rs3818361
|
|
|
0.880 |
GeneticVariation |
BEFREE |
We also independently replicate our observation of lower brain amyloid burden in risk allele carriers of rs3818361 in the Alzheimer's Disease Neuroimaging Initiative sample.
|
23022416 |
2013 |
|
rs3818361
|
|
|
0.880 |
GeneticVariation |
BEFREE |
Here, we show that two Alzheimer's disease-associated CR1 variants, rs6656401 and rs3818361, are associated with major recurrent depression in females in a population-based cohort using individuals from the Generation Scotland: Scottish Family Health Study.
|
22244847 |
2012 |
|
rs3818361
|
|
|
0.880 |
GeneticVariation |
GWASDB |
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.
|
21460840 |
2011 |
|
rs3818361
|
|
|
0.880 |
GeneticVariation |
GWASDB |
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
|
21460841 |
2011 |
|
rs3818361
|
|
|
0.880 |
GeneticVariation |
GWASCAT |
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.
|
21460840 |
2011 |
|
rs3818361
|
|
|
0.880 |
GeneticVariation |
BEFREE |
Meta-analysis of available studies (n = 31,771 individuals), including previous studies and public genome-wide association study resources (Alzheimer's Disease Neuroimaging Initiative, Translational Genomics Research Institute, and Multi-site Collaborative Study for Genotype-Phenotype Associations in Alzheimer's Disease), strongly supports the effect of rs3818361 (odds ratio = 1.180, 95% confidence interval: 1.113-1.252, P < 2.99E-8) and suggests the existence of between-study heterogeneity (P < .05).
|
21784344 |
2011 |
|
rs3818361
|
|
|
0.880 |
GeneticVariation |
BEFREE |
Unadjusted, CLU (odds ratio [OR], 0.91; 95% confidence interval [CI], 0.85-0.96 for single-nucleotide polymorphism [SNP] rs11136000), CR1 (OR, 1.14; 95% CI, 1.07-1.22; SNP rs3818361), and PICALM (OR, 0.89; 95% CI, 0.84-0.94, SNP rs3851179) were associated with AD in white individuals.
|
20697030 |
2010 |