|
rs11136000
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These associations were replicated in stage 2 (2,023 cases and 2,340 controls), producing compelling evidence for association with Alzheimer's disease in the combined dataset (rs11136000, P = 8.5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86).
|
19734902 |
2009 |
|
rs9331888
|
|
|
0.880 |
GeneticVariation |
BEFREE |
To explore mechanisms that may underlie associations between Alzheimer's disease (AD) and schizophrenia risk CLU gene and verbal memory, one of the most affected cognitive domains in both conditions, we studied DNA methylation in a region between AD-associated SNPs rs9331888 and rs9331896 in 72 healthy individuals and 73 schizophrenia patients.
|
30599442 |
2019 |
|
rs9331888
|
|
|
0.880 |
GeneticVariation |
BEFREE |
Our meta-analysis demonstrated that the rs9331888/C > G polymorphism in the clusterin gene might contribute to AD susceptibility especially in Caucasian populations.
|
28168383 |
2017 |
|
rs9331888
|
|
|
0.880 |
GeneticVariation |
BEFREE |
The clusterin (CLU) locus was an independent genetic risk factor for MCI to AD progression (CLU rs9331888: hazard ratio (HR)=1.187 (1.054-1.32); P=0.0035).
|
26976043 |
2017 |
|
rs9331888
|
|
|
0.880 |
GeneticVariation |
BEFREE |
Multivariate analysis might suggest that regular "mind-body" religious meditative activities may be negatively associated with AD in this population, as well as the CLU genotype at rs9331888.
|
26757186 |
2016 |
|
rs9331888
|
|
|
0.880 |
GeneticVariation |
BEFREE |
We observed significant association between rs9331888 polymorphism and AD in pooled populations (P = 2.26E - 07, odds ratio (OR) = 1.10, 95% confidence interval (CI) 1.06-1.14).
|
25633098 |
2016 |
|
rs9331888
|
|
|
0.880 |
GeneticVariation |
BEFREE |
Our analysis demonstrated that CLU SNP r</span>s9331888</span> might be associated with an increased AD risk in Caucasian population, but not in Asian population.
|
25703218 |
2015 |
|
rs9331888
|
|
|
0.880 |
GeneticVariation |
BEFREE |
This study indicates that the rs9331888 AD-risk variant is associated with low blood clusterin levels.
|
22258514 |
2012 |
|
rs9331888
|
|
|
0.880 |
GeneticVariation |
BEFREE |
These results suggest a biological mechanism for the genetic association of CLU with AD risk and indicate that rs9331888 is one of the functional DNA variants underlying this association.
|
21892414 |
2011 |
|
rs9331888
|
|
G |
0.880 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.
|
19734903 |
2009 |
|
rs9331888
|
|
|
0.880 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.
|
19734903 |
2009 |
|
rs2279590
|
|
|
0.840 |
GeneticVariation |
GWASCAT |
Shared genetic architecture between metabolic traits and Alzheimer's disease: a large-scale genome-wide cross-trait analysis.
|
30805717 |
2019 |
|
rs2279590
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Interestingly, rs2279590 locus has a widespread enhancer effect on two nearby genes, protein tyrosine kinase 2 beta (PTK2B) and epoxide hydrolase-2 (EPHX2); both of which have been previously associated with AD as risk factors.
|
28973302 |
2017 |
|
rs2279590
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Large-scale genome-wide association studies (GWAS) identified three single nucleotide polymorphisms rs11136000, rs2279590, and rs9331888 in CLU gene to be significantly associated with Alzheimer's disease (AD) in Caucasian ancestry.
|
25633098 |
2016 |
|
rs2279590
|
|
|
0.840 |
GeneticVariation |
BEFREE |
The CLU haplotypes AA+GA (odds ratio (OR) = 4.483; 95% CI: 1.069-18.792) of rs2279590 was correlated with AD.
|
26757186 |
2016 |
|
rs2279590
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Our results showed significant association between rs2279590 polymorphism and AD in Asian population with P = 2.00E-04 and P = 2.00E-04 using additive and recessive models, respectively.
|
24947876 |
2015 |
|
rs2279590
|
|
C |
0.840 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.
|
19734903 |
2009 |
|
rs2279590
|
|
|
0.840 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.
|
19734903 |
2009 |
|
rs9331896
|
|
|
0.820 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project.
|
31473137 |
2019 |
|
rs9331896
|
|
|
0.820 |
GeneticVariation |
BEFREE |
To explore mechanisms that may underlie associations between Alzheimer's disease (AD) and schizophrenia risk CLU gene and verbal memory, one of the most affected cognitive domains in both conditions, we studied DNA methylation in a region between AD-associated SNPs rs9331888 and rs9331896 in 72 healthy individuals and 73 schizophrenia patients.
|
30599442 |
2019 |
|
rs9331896
|
|
C |
0.820 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
|
30617256 |
2019 |
|
rs9331896
|
|
|
0.820 |
GeneticVariation |
BEFREE |
There was no interaction between rs9331896 in CLU and rs429358 (defining the ɛ4 allele) in APOE in predicting Alzheimer's disease or all dementia (P = 0.39 and P = 0.21).
|
29534716 |
2018 |
|
rs9331896
|
|
T |
0.820 |
GeneticVariation |
GWASCAT |
A novel Alzheimer disease locus located near the gene encoding tau protein.
|
25778476 |
2016 |
|
rs9331896
|
|
T |
0.820 |
GeneticVariation |
GWASCAT |
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
|
24162737 |
2013 |
|
rs9331896
|
|
T |
0.820 |
GeneticVariation |
GWASDB |
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
|
24162737 |
2013 |