|
rs541458
|
|
|
0.760 |
GeneticVariation |
BEFREE |
<b>Background:</b> Phosphatidylinositol binding clathrin assembly protein (<i>PICALM</i>) rs541458 C allele has been identified and validated to be associated with a reduction of Alzheimer's disease (AD) risk.
|
31133980 |
2019 |
|
rs541458
|
|
|
0.760 |
GeneticVariation |
BEFREE |
rs3851179 and rs541458 appear to be associated with decreased AD risk.
|
31385771 |
2019 |
|
rs541458
|
|
|
0.760 |
GeneticVariation |
BEFREE |
In a multicenter case-control association study, we studied the SNPs rs11136000 (clusterin, CLU), rs541458 (phosphatidylinositol binding clatrin assembly protein, PICALM), and rs1554948 (transcription factor A, and tyrosine kinase, non-receptor, 1, TNK1) according to the three age groups 50-65 years (group 1), 66-80 years (group 2), and 80+ years (group 3) in 569 older subjects without cognitive impairment (NoCI) and 520 Alzheimer's disease (AD) patients.
|
28631188 |
2018 |
|
rs541458
|
|
|
0.760 |
GeneticVariation |
BEFREE |
There was no significant association between SNPs of GAB2 rs2373115 (G > T) and PICALM rs541458 (C > T) and AD.
|
26611835 |
2016 |
|
rs541458
|
|
|
0.760 |
GeneticVariation |
GWASDB |
The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease.
|
21627779 |
2011 |
|
rs541458
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Of all markers tested, only rs541458 in PICALM was shown to have an effect on CSF protein levels, suggesting that the AD risk allele is associated with decreased CSF Aβ42 levels (2-tailed P = .002).
|
21300948 |
2011 |
|
rs541458
|
|
|
0.760 |
GeneticVariation |
BEFREE |
In a total of 2816 AD cases and 2706 controls, we unambiguously replicated the association of rs744373 (for BIN1) and rs541458 (for PICALM) polymorphisms with the AD risk (odds ratio [OR] = 1.26, 95% confidence interval [CI] [1.15-1.38], p = 2.9 × 10(-7), and OR = 0.80, 95% CI [0.74-0.88], p = 4.6 × 10(-7), respectively).
|
21220176 |
2011 |