|
rs2236722
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Aromatase and breast cancer: W39R, an inactive protein.
|
11916629 |
2002 |
|
rs700519
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The results suggest that the CYP19 Arg(264)Cys polymorphism modifies breast cancer</span> risk (OR=1.5, 95% CI=1.1-2.2), especially in association with alcohol consumption (P for interaction=0.04), whereas the CYP1B1 Leu(432)Val polymorphism appears to play no role here.
|
12618873 |
2003 |
|
rs2236722
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The CYP19 gene codon 39 Trp/Arg polymorphism increases breast cancer risk in subsets of premenopausal Japanese.
|
15298966 |
2004 |
|
rs700519
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The nonsynonymous SNP, rs700519 (Arg264Cys), located in haplotype block 4, was also associated with breast cancer survival.
|
17119036 |
2006 |
|
rs10046
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In a case-control study nested within a breast self-examination trial conducted in China, we examined whether CYP19A1 polymorphisms (rs1870049, rs1004982, rs28566535, rs936306, rs11636639, rs767199, rs4775936, rs11575899, rs10046, and rs4646) were associated with risk of breast cancer and fibrocystic breast conditions.
|
19064562 |
2008 |
|
rs10046
|
|
|
0.100 |
GeneticVariation |
BEFREE |
SNPs rs10046 and rs4646 may influence the HER2 status of breast cancer tumors, and rs10046 genotypes are associated with an altered DFS.
|
18049890 |
2008 |
|
rs4646
|
|
|
0.100 |
GeneticVariation |
BEFREE |
SNPs rs10046 and rs4646 may influence the HER2 status of breast cancer tumors, and rs10046 genotypes are associated with an altered DFS.
|
18049890 |
2008 |
|
rs4646
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Testing for the CYP19 rs4646 SNP as a predictive tool for breast cancer patients on antiaromatase therapy deserves prospective evaluation.
|
18245543 |
2008 |
|
rs4646
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In a case-control study nested within a breast self-examination trial conducted in China, we examined whether CYP19A1 polymorphisms (rs1870049, rs1004982, rs28566535, rs936306, rs11636639, rs767199, rs4775936, rs11575899, rs10046, and rs4646) were associated with risk of breast cancer and fibrocystic breast conditions.
|
19064562 |
2008 |
|
rs4775936
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The risk of breast cancer with (but not without) proliferative fibrocystic conditions was increased among women homozygous for the minor allele of rs1004982 (C), rs28566535 (C), rs936306 (T), and rs4775936 (C) relative to those homozygous for the major allele [age-adjusted odds ratios (95% confidence intervals), 2.19 (1.24-3.85), 2.20 (1.27-3.82), 1.94 (1.13-3.30), and 1.95 (1.07-3.58), respectively].
|
19064562 |
2008 |
|
rs1008805
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results suggest that premenopausal women carrying the G allele at CYP19 rs1008805 have increased risk of breast cancer.
|
17975727 |
2008 |
|
rs1004982
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The risk of breast cancer with (but not without) proliferative fibrocystic conditions was increased among women homozygous for the minor allele of rs1004982 (C), rs28566535 (C), rs936306 (T), and rs4775936 (C) relative to those homozygous for the major allele [age-adjusted odds ratios (95% confidence intervals), 2.19 (1.24-3.85), 2.20 (1.27-3.82), 1.94 (1.13-3.30), and 1.95 (1.07-3.58), respectively].
|
19064562 |
2008 |
|
rs28566535
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The risk of breast cancer with (but not without) proliferative fibrocystic conditions was increased among women homozygous for the minor allele of rs1004982 (C), rs28566535 (C), rs936306 (T), and rs4775936 (C) relative to those homozygous for the major allele [age-adjusted odds ratios (95% confidence intervals), 2.19 (1.24-3.85), 2.20 (1.27-3.82), 1.94 (1.13-3.30), and 1.95 (1.07-3.58), respectively].
|
19064562 |
2008 |
|
rs730154
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was no significant association between rs730154 and breast cancer, regardless of menopausal status.
|
17975727 |
2008 |
|
rs936306
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The risk of breast cancer with (but not without) proliferative fibrocystic conditions was increased among women homozygous for the minor allele of rs1004982 (C), rs28566535 (C), rs936306 (T), and rs4775936 (C) relative to those homozygous for the major allele [age-adjusted odds ratios (95% confidence intervals), 2.19 (1.24-3.85), 2.20 (1.27-3.82), 1.94 (1.13-3.30), and 1.95 (1.07-3.58), respectively].
|
19064562 |
2008 |
|
rs10046
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A common haplotype composed of the Val(80) G allele and three haplotype-tagging single nucleotide polymorphisms (rs727479, rs10046, and rs4646) in the CYP19 coding region showed a trend to association with breast cancer risk in BRCA1 carriers ages <50 years.
|
19366906 |
2009 |
|
rs10046
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study provides evidence that polymorphisms CYP17 rs743572, CYP19 rs10046 and ER-alpha rs3798577 are associated with breast cancer risk among Chinese women.
|
18629629 |
2009 |
|
rs4646
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A common haplotype composed of the Val(80) G allele and three haplotype-tagging single nucleotide polymorphisms (rs727479, rs10046, and rs4646) in the CYP19 coding region showed a trend to association with breast cancer risk in BRCA1 carriers ages <50 years.
|
19366906 |
2009 |
|
rs2236722
|
|
|
0.040 |
GeneticVariation |
BEFREE |
CYP17 (T34C), CYP19 (Trp39Arg), and FGFR2 (C906T) polymorphisms and the risk of breast cancer in south Indian women.
|
19469636 |
2009 |
|
rs1413421847
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CYP17 (T34C), CYP19 (Trp39Arg), and FGFR2 (C906T) polymorphisms and the risk of breast cancer in south Indian women.
|
19469636 |
2009 |
|
rs4646
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Testing for the rs4646 polymorphism could be a useful tool in order to orientate the treatment in elderly BC patients.
|
20144226 |
2010 |
|
rs700519
|
|
|
0.070 |
GeneticVariation |
BEFREE |
A total of 22 studies with 10,592 cases and 11,720 controls were identified, and the results showed that R264C polymorphism was not associated with breast cancer risk in overall (T vs. C: OR = 1.061, 95% CI = 0.929-1.212) or race-based populations (T vs. C for Asian: OR = 1.169, 95% CI = 1.002-1.363; for Caucasian: OR = 0.787, 95% CI = 0.597-1.037); meanwhile, for Asian individuals, 3-bpDel/Ins polymorphism showed a significantly association with breast cancer susceptibility (for allele Del vs. allele Ins: OR = 1.278, 95% CI = 1.066-1.532) while the carriers of allele (TTTA)(12) can significantly decrease breast cancer risk (OR = 0.752, 95% CI = 0.603-0.939).
|
20052540 |
2010 |
|
rs2236722
|
|
|
0.040 |
GeneticVariation |
BEFREE |
CYP17 (T-34C) and CYP19 (Trp39Arg) polymorphisms and their cooperative effects on breast cancer susceptibility.
|
20133979 |
2010 |
|
rs4646
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The common allele of rs4646, which has been associated with increased breast cancer risk, was associated with low-histological grade and small tumour size (P = 0.001 and 0.015; 1-sided, respectively).
|
20960227 |
2011 |
|
rs700519
|
|
|
0.070 |
GeneticVariation |
BEFREE |
A DNA bank of patients with gynecologic oncology, patients with breast cancer (n = 335), and healthy women (n = 530) was created, and the following single-nucleotide polymorphisms were examined: CYP1A1 M1 polymorphism, that is, T264-C transition in the 30-noncoding region; CYP1A2*1F polymorphism, that is, C734-A transversion in the CYP1A2 gene; C-T transition (Arg264Cys) in exon 7 of CYP19; and SULT1A1*2 polymorphism, that is, G638-A transition (Arg213His) in the SULT1A1 gene.
|
21977969 |
2012 |