Among the candidate genes, only the <i>LEP</i> rs7799039 polymorphism demonstrated a significant association with hyperglycemia</span> (χ<sup>2</sup>=9.879, <i>P</i>=0.008) in patients treated with risperidone; patients with the AA genotype had the highest risk (41.1%), followed by those with AG (20.8%) and GG (0%) genotypes.