Gene: NRAS ×
Source: CURATED ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121434596
rs121434596
NRAS
T 0.700 CausalMutation CLINVAR BRAF and NRAS mutations in melanoma: potential relationships to clinical response to HSP90 inhibitors. 18375819

2008
dbSNP: rs121434596
rs121434596
NRAS
T 0.700 CausalMutation CLINVAR Combined targeting of MEK and PI3K/mTOR effector pathways is necessary to effectively inhibit NRAS mutant melanoma in vitro and in vivo. 23431193

2013
dbSNP: rs121913248
rs121913248
NRAS
T 0.710 GeneticVariation CLINVAR Correlation of BRAF and NRAS mutation status with outcome, site of distant metastasis and response to chemotherapy in metastatic melanoma. 24918823

2014
dbSNP: rs1057519695
rs1057519695
NRAS
CA 0.800 CausalMutation CLINVAR Differential sensitivity of melanoma cell lines with BRAFV600E mutation to the specific Raf inhibitor PLX4032. 20406486

2010
dbSNP: rs11554290
rs11554290
NRAS
A 0.800 CausalMutation CLINVAR Differential sensitivity of melanoma cell lines with BRAFV600E mutation to the specific Raf inhibitor PLX4032. 20406486

2010
dbSNP: rs1057519695
rs1057519695
NRAS
CA 0.800 CausalMutation CLINVAR Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. 23614898

2013
dbSNP: rs1057519695
rs1057519695
NRAS
CC 0.800 CausalMutation CLINVAR Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. 23614898

2013
dbSNP: rs11554290
rs11554290
NRAS
A 0.800 CausalMutation CLINVAR Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. 23614898

2013
dbSNP: rs11554290
rs11554290
NRAS
G 0.800 CausalMutation CLINVAR Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. 23614898

2013
dbSNP: rs11554290
rs11554290
NRAS
C 0.800 CausalMutation CLINVAR Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. 23614898

2013
dbSNP: rs121913254
rs121913254
NRAS
C 0.780 CausalMutation CLINVAR Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. 23614898

2013
dbSNP: rs121913250
rs121913250
NRAS
A 0.720 CausalMutation CLINVAR Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. 23614898

2013
dbSNP: rs121913255
rs121913255
NRAS
A 0.700 CausalMutation CLINVAR Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. 23614898

2013
dbSNP: rs121913255
rs121913255
NRAS
G 0.700 CausalMutation CLINVAR Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. 23614898

2013
dbSNP: rs1057519695
rs1057519695
NRAS
CC 0.800 CausalMutation CLINVAR Distinct sets of genetic alterations in melanoma. 16291983

2005
dbSNP: rs1057519695
rs1057519695
NRAS
CA 0.800 CausalMutation CLINVAR Distinct sets of genetic alterations in melanoma. 16291983

2005
dbSNP: rs11554290
rs11554290
NRAS
A 0.800 CausalMutation CLINVAR Distinct sets of genetic alterations in melanoma. 16291983

2005
dbSNP: rs11554290
rs11554290
NRAS
C 0.800 CausalMutation CLINVAR Distinct sets of genetic alterations in melanoma. 16291983

2005
dbSNP: rs11554290
rs11554290
NRAS
G 0.800 CausalMutation CLINVAR Distinct sets of genetic alterations in melanoma. 16291983

2005
dbSNP: rs121913254
rs121913254
NRAS
C 0.780 CausalMutation CLINVAR Distinct sets of genetic alterations in melanoma. 16291983

2005
dbSNP: rs121913237
rs121913237
NRAS
G 0.740 CausalMutation CLINVAR Distinct sets of genetic alterations in melanoma. 16291983

2005
dbSNP: rs121913237
rs121913237
NRAS
T 0.740 CausalMutation CLINVAR Distinct sets of genetic alterations in melanoma. 16291983

2005
dbSNP: rs121913237
rs121913237
NRAS
A 0.740 CausalMutation CLINVAR Distinct sets of genetic alterations in melanoma. 16291983

2005
dbSNP: rs121913250
rs121913250
NRAS
G 0.720 CausalMutation CLINVAR Distinct sets of genetic alterations in melanoma. 16291983

2005
dbSNP: rs121913250
rs121913250
NRAS
A 0.720 CausalMutation CLINVAR Distinct sets of genetic alterations in melanoma. 16291983

2005