Gene: MEN1 ×
Source: CLINVAR ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs104894263
rs104894263
MEN1
C 0.810 CausalMutation CLINVAR

dbSNP: rs104894256
rs104894256
MEN1
C 0.800 CausalMutation CLINVAR

dbSNP: rs1555164707
rs1555164707
MEN1
T 0.800 CausalMutation CLINVAR

dbSNP: rs376872829
rs376872829
MEN1
G 0.800 GeneticVariation CLINVAR Germline mutations of the MEN1 gene in familial multiple endocrine neoplasia type 1 and related states. 9215689

1997
dbSNP: rs376872829
rs376872829
MEN1
G 0.800 GeneticVariation CLINVAR Menin missense mutants encoded by the MEN1 gene that are targeted to the proteasome: restoration of expression and activity by CHIP siRNA. 22090276

2012
dbSNP: rs376872829
rs376872829
MEN1
G 0.800 GeneticVariation CLINVAR The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene. 12509449

2003
dbSNP: rs376872829
rs376872829
MEN1
G 0.800 GeneticVariation CLINVAR Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. 9989505

1999
dbSNP: rs376872829
rs376872829
MEN1
G 0.800 GeneticVariation CLINVAR MEN1 is a melanoma tumor suppressor that preserves genomic integrity by stimulating transcription of genes that promote homologous recombination-directed DNA repair. 23648481

2013
dbSNP: rs376872829
rs376872829
MEN1
G 0.800 GeneticVariation CLINVAR Differential binding of the Menin tumor suppressor protein to JunD isoforms. 11221882

2001
dbSNP: rs386134256
rs386134256
MEN1
G 0.800 CausalMutation CLINVAR Cinacalcet therapy in patients affected by primary hyperparathyroidism associated to Multiple Endocrine Neoplasia Syndrome type 1 (MEN1). 26224587

2016
dbSNP: rs386134256
rs386134256
MEN1
G 0.800 CausalMutation CLINVAR Clinical Features and Response to Treatment of Prolactinomas in Children and Adolescents: A Retrospective Single-Centre Analysis and Review of the Literature. 29455199

2018
dbSNP: rs386134256
rs386134256
MEN1
G 0.800 CausalMutation CLINVAR Prospective controlled trial of a standardized meal stimulation test in the detection of pancreaticoduodenal endocrine tumours in patients with multiple endocrine neoplasia type 1. 11578300

2001
dbSNP: rs386134256
rs386134256
MEN1
G 0.800 CausalMutation CLINVAR Impact of long-acting octreotide in patients with early-stage MEN1-related duodeno-pancreatic neuroendocrine tumours. 24443791

2014
dbSNP: rs386134256
rs386134256
MEN1
G 0.800 CausalMutation CLINVAR Prognostic role of the CDNK1B V109G polymorphism in multiple endocrine neoplasia type 1. 25824098

2015
dbSNP: rs386134256
rs386134256
MEN1
G 0.800 CausalMutation CLINVAR MEN1 gene mutations in 12 MEN1 families and their associated tumors. 9820618

1998
dbSNP: rs386134256
rs386134256
MEN1
G 0.800 CausalMutation CLINVAR Screening of patients with multiple endocrine neoplasia type 1 (MEN-1): a critical analysis of its value. 19350320

2009
dbSNP: rs386134256
rs386134256
MEN1
G 0.800 CausalMutation CLINVAR Adrenal involvement in multiple endocrine neoplasia type 1: results of 7 years prospective screening. 17235589

2007
dbSNP: rs386134256
rs386134256
MEN1
G 0.800 CausalMutation CLINVAR Is Routine Screening of Young Asymptomatic MEN1 Patients Necessary? 28321559

2017
dbSNP: rs386134256
rs386134256
MEN1
G 0.800 CausalMutation CLINVAR Developing effective screening strategies in multiple endocrine neoplasia type 1 (MEN 1) on the basis of clinical and sequencing data of German patients with MEN 1. 17853334

2007
dbSNP: rs794728614
rs794728614
MEN1
A 0.800 GeneticVariation CLINVAR

dbSNP: rs386134250
rs386134250
MEN1
A 0.710 GeneticVariation CLINVAR UMD (Universal mutation database): a generic software to build and analyze locus-specific databases. 10612827

2000
dbSNP: rs386134250
rs386134250
MEN1
A 0.710 CausalMutation CLINVAR

dbSNP: rs386134250
rs386134250
MEN1
C 0.710 GeneticVariation CLINVAR Late onset asymptomatic pancreatic neuroendocrine tumor - A case report on the phenotypic expansion for MEN1. 28736585

2017
dbSNP: rs386134250
rs386134250
MEN1
A 0.710 GeneticVariation CLINVAR Clinical testing for multiple endocrine neoplasia type 1 in a DNA diagnostic laboratory. 15714081

2005
dbSNP: rs386134250
rs386134250
MEN1
A 0.710 GeneticVariation CLINVAR A patient with novel mutations causing MEN1 and hereditary multiple osteochondroma. 26515642

2015