Gene: SDHB ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs267607032
rs267607032
SDHB
A 0.700 GeneticVariation CLINVAR An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis. 19576851

2009
dbSNP: rs267607032
rs267607032
SDHB
A 0.700 GeneticVariation CLINVAR Malignant paraganglioma associated with succinate dehydrogenase subunit B in an 8-year-old child: the age of first screening? 19189136

2009
dbSNP: rs267607032
rs267607032
SDHB
A 0.700 GeneticVariation CLINVAR SDHB-related pheochromocytoma and paraganglioma penetrance and genotype-phenotype correlations. 28374168

2017
dbSNP: rs267607032
rs267607032
SDHB
A 0.700 GeneticVariation CLINVAR Succinate dehydrogenase gene mutations are strongly associated with paraganglioma of the organ of Zuckerkandl. 20418362

2010
dbSNP: rs267607032
rs267607032
SDHB
A 0.700 GeneticVariation CLINVAR The phenotype of SDHB germline mutation carriers: a nationwide study. 28490599

2017
dbSNP: rs267607032
rs267607032
SDHB
A 0.700 GeneticVariation CLINVAR Association of urinary bladder paragangliomas with germline mutations in the SDHB and VHL genes. 25683602

2015
dbSNP: rs397516833
rs397516833
SDHB
G 0.700 CausalMutation CLINVAR Germline SDHB mutations are common in patients with apparently sporadic sympathetic paragangliomas. 18382370

2008
dbSNP: rs397516833
rs397516833
SDHB
G 0.700 CausalMutation CLINVAR Evaluation of SDHB, SDHD and VHL gene susceptibility testing in the assessment of individuals with non-syndromic phaeochromocytoma, paraganglioma and head and neck paraganglioma. 23072324

2013
dbSNP: rs397516833
rs397516833
SDHB
G 0.700 CausalMutation CLINVAR Lack of utility of SDHB mutation testing in adrenergic metastatic phaeochromocytoma. 25371406

2015
dbSNP: rs397516833
rs397516833
SDHB
G 0.700 CausalMutation CLINVAR Clinical presentations, biochemical phenotypes, and genotype-phenotype correlations in patients with succinate dehydrogenase subunit B-associated pheochromocytomas and paragangliomas. 17200167

2007
dbSNP: rs397516833
rs397516833
SDHB
G 0.700 CausalMutation CLINVAR The succinate dehydrogenase genetic testing in a large prospective series of patients with paragangliomas. 19454582

2009
dbSNP: rs397516833
rs397516833
SDHB
G 0.700 CausalMutation CLINVAR Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis. 26302408

2015
dbSNP: rs397516833
rs397516833
SDHB
G 0.700 CausalMutation CLINVAR Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations. 15328326

2004
dbSNP: rs397516834
rs397516834
SDHB
A 0.700 GeneticVariation CLINVAR Identification of eight novel SDHB, SDHC, SDHD germline variants in Danish pheochromocytoma/paraganglioma patients. 27279923

2016
dbSNP: rs397516835
rs397516835
SDHB
T 0.700 CausalMutation CLINVAR Functional study in a yeast model of a novel succinate dehydrogenase subunit B gene germline missense mutation (C191Y) diagnosed in a patient affected by a glomus tumor. 19261679

2009
dbSNP: rs397516835
rs397516835
SDHB
T 0.700 CausalMutation CLINVAR Crystal structure of mitochondrial respiratory membrane protein complex II. 15989954

2005
dbSNP: rs397516835
rs397516835
SDHB
T 0.700 CausalMutation CLINVAR Crystallographic studies of the Escherichia coli quinol-fumarate reductase with inhibitors bound to the quinol-binding site. 11850430

2002
dbSNP: rs397516835
rs397516835
SDHB
T 0.700 CausalMutation CLINVAR Effect of cysteine to serine mutations on the properties of the [4Fe-4S] center in Escherichia coli fumarate reductase. 7547971

1995
dbSNP: rs397516835
rs397516835
SDHB
T 0.700 CausalMutation CLINVAR Structural basis for malfunction in complex II. 22904323

2012
dbSNP: rs397516835
rs397516835
SDHB
T 0.700 CausalMutation CLINVAR Somatic mutations in H-RAS in sporadic pheochromocytoma and paraganglioma identified by exome sequencing. 23640968

2013
dbSNP: rs397516836
rs397516836
SDHB
A 0.700 CausalMutation CLINVAR Tumour risks and genotype-phenotype correlations associated with germline variants in succinate dehydrogenase subunit genes SDHB, SDHC and SDHD. 29386252

2018
dbSNP: rs397516836
rs397516836
SDHB
A 0.700 CausalMutation CLINVAR Succinate dehydrogenase gene mutations are strongly associated with paraganglioma of the organ of Zuckerkandl. 20418362

2010
dbSNP: rs397516836
rs397516836
SDHB
A 0.700 CausalMutation CLINVAR Rapid-sequence MRI for long-term surveillance for paraganglioma and phaeochromocytoma in patients with succinate dehydrogenase mutations. 27634942

2016
dbSNP: rs397516836
rs397516836
SDHB
A 0.700 CausalMutation CLINVAR SDHB-associated renal oncocytoma suggests a broadening of the renal phenotype in hereditary paragangliomatosis. 19184535

2009
dbSNP: rs397516836
rs397516836
SDHB
A 0.700 CausalMutation CLINVAR Clinical presentations, biochemical phenotypes, and genotype-phenotype correlations in patients with succinate dehydrogenase subunit B-associated pheochromocytomas and paragangliomas. 17200167

2007